A Langerhans cell (LC) is a tissue-resident macrophage of the skin [2] once thought to be a resident dendritic cell. [3] These cells contain organelles called Birbeck granules . They are present in all layers of the epidermis and are most prominent in the stratum spinosum . [ 4 ]

2023年9月21日 · What Is Langerhans Cell Histiocytosis? You may know that white blood cells are your body’s infection fighters. But if your body makes too much of a type of immune cell called …

2023年12月26日 · Langerhans cell histiocytosis is a rare disorder that occurs when a type of immune system cell called Langerhans cells build up in your child’s body. When these cells accumulate, it can cause tissue damage and tumors to form.

2024年4月18日 · Langerhans cell histiocytosis (LCH) is a neoplastic disorder that arises from an expansion of early myeloid cells in the bone marrow compartment, most commonly due to a clonal mutation in the RAS/MAP Kinase signaling pathway.

Langerhans cell histiocytosis (LCH) is a disorder that primarily affects children, but is also found in adults of all ages. People with LCH produce too many Langerhans cells or histiocytes, a form of white blood cell found in healthy people that is supposed to protect the body from infection.

Langerhans cell histiocytosis is a disorder in which excess immune system cells called Langerhans cells build up in the body. Langerhans cells, which help regulate the immune system, are normally found throughout the body, especially in the skin, lymph nodes, spleen, lungs, liver, and bone marrow.

Langerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. Symptoms range from isolated bone lesions to multisystem disease. [1]

2024年6月6日 · Langerhans Cell Histiocytosis (LCH) treatment depends on where it is found in the body and whether the LCH is low or high risk. Treatment can include chemotherapy, surgery, radiation therapy, photodynamic therapy, immunotherapy, and targeted therapy. Learn more in this expert-reviewed summary.

2021年4月26日 · Langerhans cells are a type of immune cell found primarily in the epidermis that have important roles in the stimulation and suppression of the adaptive immune response. They are members of the dendritic cell family and function as antigen-presenting cells.

Langerhans cell histiocytosis is a rare condition, slightly more common in boys than girls, affecting around one in 5 million children and fewer adults. Langerhans cell histiocytosis may develop at any age but most commonly occurs in childhood (1–3 years of age).