2022年12月30日 · Although there are many other less abundant proteins in the extracellular matrix, laminin is the final ECM molecule to be discussed in this chapter. Laminins are a family …

Laminins are heterotrimeric proteins with a high molecular mass (~400 to ~900 kDa) and possess three different chains (α, β, and γ) encoded by five, four, and three paralogous genes in …

We discuss current ideas of how laminin matrices are assembled, the role of matrix receptors in this process and how laminin-associated proteins modulate matrix deposition.

The ECM component laminin uses multiple stretches of amino acid sequences distributed widely in the structure to formulate complicated 3D pharmacophore, in order to secure the specificity …

2019年11月5日 · A major factor driving the differentiation towards hepatocellular specification is the initial supporting ECM for hPSCs as well as supplementation with liver-specific ECM. In …

Laminin the best known member of a family of basement membrane glycoproteins that play a role in cell adhesion, migration, growth and differentiation (2). Laminins also promote neurite …

2020年1月14日 · Here, we report that laminin forms the in vivo ECM niche for trophoblast stem cells (TSCs), the tissue stem cells of the placenta. TSCs expressed fibronectin-binding, …

2009年12月15日 · We discuss current ideas of how laminin matrices are assembled, the role of matrix receptors in this process and how laminin-associated proteins modulate matrix deposition.

portant cellular functions attributed to laminin include stimulation of growth and differentiation, neurite out-growth promotion, and mediation of cell communica-tion. Laminin is the first ECM …

The extracellular matrix (ECM) is a consistent yet dynamic influence on the metastatic capacity of SCCs. The ECM encompasses a milieu of structural proteins, signaling molecules, and …