Initially, two lipoxins were identified, lipoxin A 4 (LXA 4) and LXB 4, but more recent studies have identified epimers of these two LXs: the epi-lipoxins, 15-epi-LXA 4 and 15-epi-LXB 4 …

2017年8月2日 · Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, is produced from arachidonic acid. LXA4 exerts potent dual anti-inflammatory and pro-resolving …

2024年4月26日 · LXA4 treatment protects against oxidative stress-induced H 2 O 2 damage by reducing ROS, lactate dehydrogenase (LDH), and malondialdehyde (MDA) leakage, while …

Lipoxin A4 is a C20 hydroxy fatty acid having (5S)-, (6R)- and (15S)-hydroxy groups as well as (7E)- (9E)-, (11Z)- and (13E)-double bonds. It has a role as a metabolite and a human …

2024年11月21日 · The preclinical study, published in Cardiovascular Diabetology, found LXA4, which is known for its "calming agent" action in turning off the body's inflammatory response …

Lipoxin A4 (LXA4) is an endogenous lipid mediator that requires cell-cell interaction or cell-platelet interaction for its synthesis. The roles of LXA4 on inflammatory responses are well described, …

2016年1月5日 · Our study confirmed that LXA4 provided neuroprotection in early brain injury through suppressing inflammation via FPR2/p38 signaling pathway. LXA4 might be a …

LXA4 protects lung tissue by inhibiting neutrophil recruitment, partly through the CXCL2/MMP-9 signaling pathway. CXCL2 and MMP-9 are mainly expressed by resident macrophages and …

Some studies have suggested the mechanism by which LXA4 performs its function in neuroprotection. LXA4 alleviates neuroinflammation by regulating T cell responses and …

Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dual pro-resolving and anti-inflammatory properties. Lipoxin A4 inhibits proliferation and …