Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. [5] [6] LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group …

2024年12月25日 · LRP6 (LDL Receptor Related Protein 6) is a Protein Coding gene. Diseases associated with LRP6 include Coronary Artery Disease, Autosomal Dominant 2 and Tooth …

LRP6 is a member of the low-density lipoprotein receptor superfamily of cell-surface receptors. It is required for the activation of the Wnt/β-catenin signalling pathway. LRP6 is detected in …

2020年9月24日 · Our study identifies LRP6 as a critical regulator of cardiomyocyte proliferation, which may lead to the development of a novel molecular strategy to promote myocardial …

LRP6/filamentous-actin signaling facilitates osteogenic commitment in mechanically induced periodontal ligament stem cells. A genetic variant of the Wnt receptor LRP6 accelerates …

2017年7月11日 · Low-density lipoprotein receptor protein 6 (LRP6) is a Wnt co-receptor with essential functions in the Wnt/β-catenin pathway, and mutations in LRP6 gene are linked to …

Notably, the low-density lipoprotein receptor-related protein 6 (LRP6), an indispensable co-receptor for WNT, is frequently overexpressed in colorectal, liver, breast and pancreatic …

LRP6 is highly expressed in tumors of liver cancer patients, and overexpression of LRP6 promotes liver cancer cell proliferation and tumor growth (Tung et al., 2012). Several …

2022年1月10日 · LRP6 is essential for the proper development of different organs in vertebrates, such as Xenopus laevis, chickens, and mice. In human, LRP6 overexpression and mutations …

2020年12月9日 · The Wnt co-receptor Lrp6 was fused to APEX2 and used to biotinylate targets that are recruited near the receptor during Wnt signaling at different time periods. Lrp6 …