Dec 25, 2024 · The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney.

Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the LRP2 gene. [5][6][7] LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin [8] and later LRP2.

ldl 受体相关蛋白 2： 由该基因编码的蛋白质，低密度脂蛋白相关蛋白 2 (lrp2) 或巨蛋白，是一种多配体内吞受体，在许多不同组织中表达，但主要在吸收性上皮组织 (如肾脏) 中表达。

Feb 16, 2023 · The low-density lipoprotein (LDL) receptor-related protein 2 (LRP2 or megalin) is representative of the phylogenetically conserved subfamily of giant LDL receptor-related proteins, which function in endocytosis and are implicated in diseases of the kidney and brain. Here, we report high-resolution c …

Feb 6, 2023 · The structures reveal LRP2 to be a molecular machine that adopts a conformation for ligand binding at the cell surface and for ligand shedding in the endosome. LRP2 forms a homodimer, the conformational transformation of which is governed by pH-sensitive sites at both homodimer and intra-protomer interfaces.

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney.

低密度脂蛋白受体相关蛋白 2（lrp2），是一种细胞表面蛋白，属于内吞性受体并在内吞作用中发挥作用，先前的研究发现其与肾脏和大脑疾病存在密切关联。 作为 lrp 蛋白家族的一个重要成员，lrp2 存在于从蠕虫到人类的各种生物体内。

Feb 21, 2023 · 在一项新的研究中，来自美国哥伦比亚大学等研究机构的研究人员首次揭示了一种生死攸关的蛋白---LRP2---的三维结构，其清晰度足以最终揭示它是如何起作用的。 细节往往是决定成败的关键。 对于协调生命分子业务的蛋白来说，它们的细节中存在着魔鬼和天使，小到组成蛋白的原子。 正是在这种结构性的细枝末节上，健康和疾病，甚至生命和死亡的平衡可能会发生转折。 在一项新的研究中，来自美国哥伦比亚大学等研究机构的研究人员首次揭示了一种生死攸 …

The LRP2 gene provides instructions for making a protein called megalin, which functions as a receptor. Receptor proteins have specific sites into which certain other proteins, called ligands, fit like keys into locks. Together, ligands and their receptors trigger signals that affect cell development and function.

Dec 10, 2024 · The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney.