We demonstrate that LPA stimulates the production and secretion of fibrogenic peptides, PDGF-B and CTGF, by cultured kidney proximal tubule cells through a mechanism that transactivates …

1998年7月21日 · Inhibition of RTK activity abolished LPA-mediated RTK and Shc tyrosine phosphorylation as well as ERK activation. Our results document a cross-talk at the receptor …

2019年12月1日 · In L cells lacking EGFR, LPA-induced Shc and ERK activation are mediated by the platelet-derived growth factor receptor (PDGFR) and these responses are inhibited by a …

Here we show that increasing the catalytic activity of LPP1 decreased the pertussis toxin-sensitive stimulation of fibroblast migration by LPA and an LPA-receptor agonist that could not be …

2024年7月6日 · Lung parenchymal hypoxia has emerged as a cardinal feature of idiopathic pulmonary fibrosis (IPF). Hypoxia promotes cancer cell invasion and metastasis through …

To our knowledge, this study provides the first evidence that LPA stimulates human PDLF wound healing responses and interacts positively with PDGF to regulate these actions. These results …

We show that lysophosphatidic acid (LPA), a ubiquitous phospholipid that is increased at sites of injury and inflammation, signals through LPA2 receptors and Gαq proteins of cultured proximal …

In L cells lacking EGFR, LPA-induced Shc and ERK activation are mediated by the platelet-derived growth factor receptor (PDGFR) and these responses are inhibited by a specific …

ligand-independent activation of RTKs (27-31). LPA, endo-thelin, or thrombin activate the epidermal growth factor receptor in Rat-1 cells in the absence of EGF. Inhibition of EGFR …

Given the importance of LPA 1 and RTKs (PDGFR, FGFR, and VEGFR) for invadosome formation under hypoxic conditions, we sought to determine whether LPA 1 is involved in the …