LOXL2 is an enzyme that is up-regulated in several types of cancer and is associated with a poorer prognosis. [8] [9] LOXL2 changes the structure of histones (proteins that are attached to DNA) [10] and thus changes the shape of the cells, making it easier for the cancer cells to metastasize. [11]

2024年12月25日 · LOXL2 (Lysyl Oxidase Like 2) is a Protein Coding gene. Diseases associated with LOXL2 include Hyperostosis Cranialis Interna and Cutis Laxa. Among its related pathways are Collagen chain trimerization and Elastic fibre formation. Gene Ontology (GO) annotations related to this gene include chromatin binding and electron transfer activity.

2020年12月1日 · Lysyl oxidase-like 2 (LOXL2) is a copper and lysine tyrosyl-quinone (LTQ)-dependent amine oxidase belonging to the lysyl oxidase (LOX) family, the canonical function of which is to catalyze the crosslinking of elastin and collagen in the extracellular matrix (ECM).

Targeting LOXL2 has become a potential therapeutic strategy to combat many types of cancers. Here, we provide an overview of the regulation and downstream effectors of LOXL2 and discuss the intracellular role of LOXL2 in cancer.

2023年4月7日 · Here we show that Factor Xa (FXa) is a protease that processes LOXL2 at Arg-338. Processing by FXa does not affect the enzymatic activity of soluble LOXL2.

Lysyl Oxidase Like 2 (LOXL2) belongs to the lysyl oxidase (LOX) family, which comprises five lysine tyrosylquinone (LTQ)-dependent copper amine oxidases in humans. In 2003, LOXL2 was first identified as a promoter of tumour progression and, over the ...

Objective: The lysyl oxidase-like protein 2 (LOXL2) contributes to tumour progression and metastasis in different tumour entities, but its role in pancreatic ductal adenocarcinoma (PDAC) has not been evaluated in immunocompetent in vivo PDAC models.

LOXL2 inhibition can decrease cell numbers, proliferation, colony formations, and cell growth, and it can induce cell cycle arrest and increase apoptosis. The development of a new humanized IgG4 monoclonal antibody against LOXL2 could open the window of a new antifibrogenic treatment.

2023年9月21日 · Given the significant role of LOXL2 in numerous cancers, extensive efforts are underway to identify specific inhibitors that could potentially improve patient prognosis. In this review, we aim to provide a comprehensive overview of two decades of research on the role of LOXL2 in cancer.

LOXL2 in cancer: regulation, downstream effectors and novel roles. Lysyl oxidase-like 2 promotes esophageal squamous cell carcinoma cell migration independent of catalytic activity. LOXL2 promotes oncogenic progression in alveolar rhabdomyosarcoma independently of …