什么是ll-37？ LL-37是发现的唯一存在于人体中的Cathelicidin类抗菌肽，由Cathelicidin蛋白N端的37个氨基酸组成，起始氨基酸分别是L-L，故得名LL-37。 LL-37是 中性粒细胞 中的主要蛋白质，广泛存在于中性粒细胞、骨髓、子宫颈及阴道鳞状上皮等细胞中。

The human antimicrobial peptide LL-37 has been considered as a potential alternative to conventional antibiotics as it displays broad spectrum antibacterial and anti-biofilm activities as well as immunomodulatory functions. While LL-37 has shown promising results, it has yet to receive regulatory approval as a peptide antibiotic.

Cathelicidin antimicrobial peptide (CAMP) is an antimicrobial peptide encoded in the human by the CAMP gene. [1] . The active form is LL-37. In humans, CAMP encodes the peptide precursor CAP-18 (18 kDa), which is processed by proteinase 3 -mediated extracellular cleavage into the active form LL-37. [2][1]

LL-37 是人类唯一一个 Cathelicidins家族 的抗菌肽，由37个氨基酸残基组成的两 亲性螺旋肽，已被证明具有广谱的抗菌活性 。本文重点归纳总结LL-37的抗菌和免疫调节活性，以及细菌和真菌对其产生抗性的研究进展 。

LL-37, expressed on the surface of neutrophils is recognized by anti-LL-37 autoantibodies, which promotes NETosis, generating a source of additional LL-37 DNA complexes. However, LL-37 has strong anti-inflammatory effects such as neutralization of TLR4 activation by LPS, downmodulation of inflammatory cytokine responses and preventing invasion ...

LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing.

Aug 4, 2020 · LL-37 17–29 resembles, in sequence and in the ability to form amphipathic helical fibrils, the bacterial cytotoxic PSMα3 peptide that assembles into cross-α amyloid fibrils. This argues helical,...

LL-37是人类唯一一个Cathelicidins家族的抗菌肽，由37个氨基酸残基组成的两亲性螺旋肽，已被证明具有广谱的抗菌活性。 本文重点归纳总结LL-37的抗菌和免疫调节活性，以及细菌和真菌对其产生抗性的研究进展。 关键词： 抗菌肽 LL-37 抗菌机制 免疫调节. Abstract: Innate immune system is the first line of defense for microorganisms to invade the host, which is very important for the survival and health of human body.

LL‐37 是 组织蛋白酶抑制素 家族中唯一在人体内的成员，对革兰阴性菌和革兰阳性菌均有抑制作用。 该文从LL‐37活性结构域进行分析，阐述了LL‐37在抗菌、抗内毒素、 创伤愈合 、 免疫调节 等方面的作用机制及临床治疗潜力，展望了其应用前景，为新药研发、食品防腐和动物饲料添加提供思路。 抗生素曾在世界上占有重要的地位，拯救过无数人的生命，在农药、食品添加剂、畜牧类养殖中发挥了重要作用，成为热门的抗菌药。 然而，在 20 世纪70年代后，研发出高效抗生素却 …

LL-37, the only human cathelicidin-derived antimicrobial peptide, has long been a popular research subject because of its special abilities and vast applications. In the past 15 years, hundreds of papers have been published with LL-37 being their primary focus.