2016年4月11日 · Herein we report that leucine-rich repeat-containing G-protein-coupled receptor 4 (LGR4, also called GPR48) is another receptor for RANKL. LGR4 competes with RANK to bind RANKL and...

2024年12月25日 · LGR4 (Leucine Rich Repeat Containing G Protein-Coupled Receptor 4) is a Protein Coding gene. Diseases associated with LGR4 include Delayed Puberty, Self-Limited and Bone Mineral Density Quantitative Trait Locus 17 .

In cancer, LGR4 participates in tumor progression, invasion, and metastasis. Furthermore, recent evidence reveals that LGR4 is essential for the regulation of the cancer stem cell population by controlling self-renewal and regulating stem cell properties. This review summarizes the function of LGR4 and its ligands in normal and malignant processes.

We found that men with prostate cancers expressing high levels of the G protein–coupled receptor LGR4 had a significantly shorter recurrence-free survival compared with patients with cancers having low LGR4 expression. LGR4 expression was elevated in human prostate cancer cell lines with metastatic potential.

2023年7月11日 · In this review, we highlight LGR4 dysfunction in clinical diseases, animal models, and pathophysiological changes, discuss their known ligands and downstream signaling pathways, and identify unresolved questions and future perspectives of this new receptor.

LGR4 is a transmembrane receptor of the GPCRs superfamily that is characterized by a large extracellular Leucine-rich domain that recognizes and interacts with its ligands (Van Loy et al., 2008), thus regulating numerous cellular processes . Many studies have explored the mechanisms of LGR4 gene.

2025年1月24日 · This review discusses the molecular characteristics, signaling pathways, and role of LGR4 in osteoimmunology, with a particular focus on its interactions with RANKL during osteoclast differentiation, while identifying gaps that warrant further research.

2025年2月8日 · LGR4, Not LGR5, Enhances hPSC Hematopoiesis by Facilitating Mesoderm Induction via TGF-Beta Signaling Activation. The Role of LGR4 (GPR48) in Normal and Cancer Processes. LGR4 deficiency results in delayed puberty …

2018年1月1日 · LGR4, also known as GPR48, is a protein receptor first discovered in 1998. It is homologous to LGR5. The gene encoding LGR4 was mapped to 11p14→p13 and is highly conserved in mammals. The complete Lgr4 gene spans more than 60 kb with 18 exons and 17 introns (Loh et al. 2001).

2025年2月8日 · Lgr4, which regulates eye, kidney, testis, ovary, and uterine organ development as well as mental development through genetic and epigenetic surveillance, is a novel candidate gene for the pathogenesis of AGR syndrome; Lgr4 activates Sox2 to regulate mammary development and stem cell functions via Wnt/beta-catenin/Lef1.