2024年12月25日 · LEF1 (Lymphoid Enhancer Binding Factor 1) is a Protein Coding gene. Diseases associated with LEF1 include Split Hand-Foot Malformation and Ectrodactyly And Ectodermal Dysplasia Without Cleft Lip/Palate. Among its related pathways are Autodegradation of the E3 ubiquitin ligase COP1 and ncRNAs involved in Wnt signaling in hepatocellular …

2017年6月1日 · Lymphoid enhancer-binding factor 1 (LEF1), a member of the T-cell Factor (TCF)/LEF1 family of high-mobility group transcription factors, is a downstream mediator of the Wnt/β-catenin signaling pathway, but can also modulate gene transcription independently.

Recently, the role of lymphocyte enhancer-binding factor 1 (LEF1) in CLL was elucidated being highly expressed and seeming to have a prognostic value. Our aim was to test the applicability of LEF1 as marker for CLL in a diagnostic setting.

2021年10月6日 · Using high-throughput chromosome-conformation-capture sequencing, we demonstrate that Tcf1/Lef1 are important for maintaining three-dimensional genome organization at multiple scales in CD8 + T...

2025年2月8日 · LEF1 Drives a Central Memory Program and Supports Antitumor Activity of Natural Killer T Cells. The beta-catenin-LINC00183-miR-371b-5p-Smad2/LEF1 axis promotes adult T-cell lymphoblastic lymphoma progression and chemoresistance.

Lymphoid enhancer-binding factor 1 (LEF1), a member of the T-cell Factor (TCF)/LEF1 family of high-mobility group transcription factors, is a downstream mediator of the Wnt/β-catenin signaling pathway, but can also modulate gene transcription independently.

LEF-1 is a DNA-binding protein in the control of transcription and has been shown to be central in organogenesis where there is bidirectional interaction of mesenchyme and epithelia.

2025年2月8日 · Data indicate Lef1 binds Pax3 & the complex binds to Lef1 promoter at Lef1 binding sites to enhance transcription of Lef1. In adult mouse brain, beta-catenin and LEF1 accumulate in the nuclei of neurons specifically in the thalamus.

2023年7月20日 · We found that functional LEF1 and LEF1 regulon activity is reduced with age in multiple immune cell types from different human and murine tissues. We also showed that two LEF1 isoforms are severely dysregulated in aged lungs.

Recently, the role of lymphocyte enhancer-binding factor 1 (LEF1) in CLL was elucidated being highly expressed and seeming to have a prognostic value. Our aim was to test the applicability of LEF1 as marker for CLL in a diagnostic setting.