氨基酸转运蛋白 LAT1 (SLC7A5) 作为癌症诊断和治疗 ... - X-MOL
lat1 对癌细胞生长至关重要，因为 lat1 的药理学抑制和敲低/敲除可抑制癌细胞的增殖和异种移植肿瘤的生长。 LAT1 的抑制通过下调 mTORC1 信号通路和调动癌细胞中的一般氨基酸控制 …
“脑癌”潜力靶点LAT1，药物设计思路清晰 - 网易
Sep 30, 2021 · LAT（L-type amino transporters），即L型氨基酸转运体，主要功能为中性氨基酸包括必须氨基酸的转运，亚型按照时间发现顺序依次为LAT1、LAT2、LAT3、LAT4，其 …
Structure of the human LAT1–4F2hc heteromeric amino acid …
Mar 13, 2019 · LAT1 forms a heteromeric amino acid transporter complex with 4F2 cell-surface antigen heavy chain (4F2hc; also known as SLC3A2)—a type II membrane glycoprotein that is …
L-Type amino acid transporter 1 as a target for drug delivery
Due to the significant up-regulation of LAT1 expression in several human tumors, LAT1 has been an attractive transporter for targeted delivery of amino acid-derived anticancer drugs and …
Structural basis of anticancer drug recognition and amino acid ...
Feb 14, 2025 · LAT1 (SLC7A5) transports large neutral amino acids and plays pivotal roles in cancer proliferation, immune response and drug delivery. Despite recent advances in structural...
SLC7A5 Gene - GeneCards | LAT1 Protein | LAT1 Antibody
Dec 25, 2024 · (Microbial infection) In case of hepatitis C virus/HCV infection, the complex formed by SLC3A2 and SLC7A5/LAT1 plays a role in HCV propagation by facilitating viral entry into …
Amino acid transporter LAT1 (SLC7A5) as a molecular target for …
Feb 1, 2022 · LAT1 regulates cell proliferation upstream of mTORC1. In addition to inhibiting mTORC1, LAT1 inhibitors activate the GAAC pathway to suppress translation initiation. LAT1 …
The Role of Large Neutral Amino Acid Transporter (LAT1) in Cancer
LAT1 (also known as SLC7A5), is defined as a heteromeric amino acid transporter (HAT) interacting with the glycoprotein CD98 (SLC3A2) through a conserved disulfide to uptake not …
氨基酸转运载体 LAT1 研究进展 - 豆丁网
Jan 9, 2015 · lat1介导的氨基酸转运对于蛋白质的合成和细胞的 生长增殖等非常重要，有必要对LAT蛋白活性调节 因子进行深入研究；细胞水平上对癌变细胞和正常
深入了解大型中性氨基酸转运蛋白 1 (LAT1) 的结构、功能和配体发 …
大中性氨基酸转运蛋白 1（LAT1 或 SLC7A5）是一种不依赖钠和 pH 的转运蛋白，为细胞提供必需氨基酸（例如亮氨酸、苯丙氨酸）。 它在血脑屏障 (BBB) 中发挥着重要作用，促进甲状腺激 …