2018年10月24日 · Kv1.2 is a prominent voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. We explored multi-protein …

Potassium Channel Kv1.2 is a type of voltage-gated potassium channel that is located in the juxatanodal domain of axons. It primarily produces a sustained outward potassium current and …

2025年2月13日 · We present near-atomic-resolution cryoEM structures of the mammalian voltage-gated potassium channel Kv1.2 in open, C-type inactivated, toxin-blocked and sodium …

2005年8月5日 · We investigated the mechanism by which these channels sense cell membrane voltage by determining the x-ray crystal structure of a mammalian Shaker family potassium ion …

In this study, by applying a novel normal-mode-based X-ray crystallographic refinement method to the original diffraction data and structural model, we established the structure of full-length …

Kv1.1 and Kv1.2 knockout mice both have seizures beginning early in development; however, each express a different seizure type (pathway), although the channels are from the same …

2024年12月18日 · Fluorescence, a high level of membrane expression of K-Kv1.2, and a high affinity of the HgTx-G ligand for the Kv1.2 channel significantly facilitate the use of K-Kv1.2, …

2024年12月18日 · The results indicated a correlation between KCNA2 expression and patient survival. The data also demonstrated that KCNA2/Kv1.2 is a direct target of EWS::FLI1, and …

Two epilepsy-associated variants in KCNA2 (KV 1.2) at position H310 oppositely affect channel functional expression. An epilepsy-associated KV1.2 charge-transfer-center mutation impairs …

Voltage-gated potassium Kv1.2 channels play pivotal role in maintaining of resting membrane potential and, consequently, regulation of cellular excitability of neurons. Endogenously …