
Slc7a5 regulates Kv1.2 channels and modifies functional ... - Nature
2018年10月24日 · Kv1.2 is a prominent voltage-gated potassium channel that influences action potential generation and propagation in the central nervous system. We explored multi-protein …
Potassium Channel Kv1.2 - an overview | ScienceDirect Topics
Potassium Channel Kv1.2 is a type of voltage-gated potassium channel that is located in the juxatanodal domain of axons. It primarily produces a sustained outward potassium current and …
CryoEM structures of Kv1.2 potassium channels, conducting and …
2025年2月13日 · We present near-atomic-resolution cryoEM structures of the mammalian voltage-gated potassium channel Kv1.2 in open, C-type inactivated, toxin-blocked and sodium …
Voltage Sensor of Kv1.2: Structural Basis of ... - Science
2005年8月5日 · We investigated the mechanism by which these channels sense cell membrane voltage by determining the x-ray crystal structure of a mammalian Shaker family potassium ion …
Structure of the full-length Shaker potassium channel Kv1.2 by …
In this study, by applying a novel normal-mode-based X-ray crystallographic refinement method to the original diffraction data and structural model, we established the structure of full-length …
Kv1.1 and Kv1.2: similar channels, different seizure models
Kv1.1 and Kv1.2 knockout mice both have seizures beginning early in development; however, each express a different seizure type (pathway), although the channels are from the same …
New High-Affinity Peptide Ligands for Kv1.2 Channel: Selective
2024年12月18日 · Fluorescence, a high level of membrane expression of K-Kv1.2, and a high affinity of the HgTx-G ligand for the Kv1.2 channel significantly facilitate the use of K-Kv1.2, …
Transcriptional regulation of KCNA2 coding Kv1.2 by EWS::FLI1
2024年12月18日 · The results indicated a correlation between KCNA2 expression and patient survival. The data also demonstrated that KCNA2/Kv1.2 is a direct target of EWS::FLI1, and …
KCNA2 potassium voltage-gated channel subfamily A member 2
Two epilepsy-associated variants in KCNA2 (KV 1.2) at position H310 oppositely affect channel functional expression. An epilepsy-associated KV1.2 charge-transfer-center mutation impairs …
The Role of Kv1.2 Channel in Electrotaxis Cell Migration
Voltage-gated potassium Kv1.2 channels play pivotal role in maintaining of resting membrane potential and, consequently, regulation of cellular excitability of neurons. Endogenously …
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