Ku80 is a protein that, in humans, is encoded by the XRCC5 gene. [5] Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for …

Ku80 is important for the repair of DNA double-strand breaks by the nonhomologous end-joining protein, Ku70. The Ku80–Ku70 heterodimer (Ku) binds to DNA ends, nicks, gaps, and hairpins.

Understanding the molecular basis of c-NHEJ has major outcomes in several fields, including radiobiology, cancer therapy, immune disease, and genome editing. The heterodimer Ku70/80 …

2024年2月1日 · Based on our findings, we suggest that the high efficiency of Ku80 knockout in human HCT116 cells makes it a promising model for characterizing SVs in the context of 3D …

Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human Ku proteins is around 70 kDa and 80 kDa. …

Ku70 or Ku80, we performed in vitro pull-down experiments us-ing purified recombinant His-tagged green fluorescent protein (His-GFP), His-cGAS-GFP, His-Ku80, or His-Ku70 from …

2004年5月1日 · Ku is a heterodimer composed of two subunits — Ku70 and Ku80 — that binds to DNA ends in a sequence-independent manner. From crystallographic studies, we know that it …

Our results suggest that the C-terminal region of Ku80 is dispensable for interaction with Ku70 and for DNA end binding but is required for optimal DNA-PK activity.

Previously we showed that control and ku80 −/− mice presented with external signs of inflammation as they aged; however, these signs were observed earlier in ku80 −/− mutant …

2016年12月20日 · Studies showed that the Ku70/80 heterodimer is a key-player in the double-stranded DNA repair pathway nonhomologous end-joining (NHEJ) and binds to DNA termini …