Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161 (cluster of differentiation 161), is a human gene. [5]

Dec 25, 2024 · KLRB1 (Killer Cell Lectin Like Receptor B1) is a Protein Coding gene. Diseases associated with KLRB1 include Inflammatory Bowel Disease 18 and Dermatitis, Atopic, 5 . Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation .

Feb 19, 2021 · 本研究的实验策略 紧接着，针对克隆扩展的肿瘤浸润t细胞的分析进一步确定了nk基因klrb1 （编码cd161） 作为候选抑制性受体。 为了确定阻断CD161通路是否能恢复T细胞攻击胶质瘤细胞的能力，研究人员通过两种方式使其丧失功能—— 敲除编码CD161的KLRB1基因 或 ...

Feb 8, 2025 · Title: KLRB1 defines an activated phenotype of CD4+ T cells and shows significant upregulation in patients with primary Sjögren's syndrome. Down-regulation of KLRB1 is associated with increased cell growth, metastasis, poor prognosis, as well as a dysfunctional immune microenvironment in LUAD.

Jul 29, 2015 · CD161, or KLRB1, is a C-type lectin-like receptor expressed by the majority of natural killer (NK) cells 5 and in a subset of T cells, 6 and is particularly enriched in populations found in the...

他们的研究表明，从基因上删除编码cd161的klrb1，或使用抗体阻断cd161，可以在体外增强t细胞介导的对胶质瘤细胞的杀伤作用，在体内增强抗肿瘤功能。 研究还表明，同样的途径可能与其它形式的癌症有关。

KLRB1 蛋白包含一个具有 C 型凝集素特征的多个基序的胞外结构域、一个跨膜结构域和一个细胞质结构域。 KLRB1 蛋白被归类为 II 型膜蛋白，因为它具有外部 C 末端。[RefSeq 提供，2008 年 7 月]

Jun 24, 2024 · klrb1 成为 hcc 中一种有前途的生物标志物，其对外周血 nk 和 t 细胞的下调表明潜在的预后价值。进一步阐明 klrb1 在 hcc 中的作用可能为靶向免疫疗法的开发和改善患者预后铺平道路。 "点击查看英文标题和摘要"

klrb1蛋白包含一个具有c型凝集素特征性几个基序的细胞外结构域，一个跨膜结构域和一个细胞质结构域。 KLRB1蛋白由于具有外部C末端，因此被归为II型膜蛋白。

In our study, we showed that KLRB1 was upregulated in tumor tissues, especially in seminomas, and that elevated KLRB1 expression correlated with adverse clinicopathological features of TGCT. This provides insights into the expression and biological function of KLRB1 in TGCT, which suggests its potential function as an oncogene and prognostic ...