2022年2月8日 · Although serum KL-6 is a stable biomarker that is not affected by lung infection and smoking status, those in the IPF arm with antinuclear antibodies demonstrated higher KL-6 levels. KL-6 levels, along with poor pulmonary function and high radiologic fibrosis scores, are indicative of the severity of an individual’s IPF, but not of poor survival.

2022年12月7日 · Potential soluble biomarkers in peripheral blood/bronchoalveolar lavage fluid (BALF) for the diagnosis of systemic sclerosis interstitial lung disease (SSc-ILD) include Krebs von den Lungen-6 (KL-6), surfactant protein-D (SP-D), and interleukin-8 (IL-8), according to a systematic review and meta-analysis published in Thorax.

2023年4月13日 · “Ca15-3 may be a lower-cost, more accessible surrogate for KL-6 in future biomarker assessment.” Disclosure: Research grants for this study were received from Arthritis Australia and Roche Pharmaceuticals. Some of the study authors declared affiliations with biotech, pharmaceutical, and/or device companies.