2024年12月25日 · KIF20A (Kinesin Family Member 20A) is a Protein Coding gene. Diseases associated with KIF20A include Cardiomyopathy, Familial Restrictive, 6 and Familial Isolated Restrictive Cardiomyopathy. Among its related pathways are Golgi-to-ER retrograde transport and Cell Cycle, Mitotic.

In this review, we summarized all the cancer that highly expressed KIF20A, described the role of KIF20A in cancer. We also organized phase I and phase II clinical trials of KIF20A peptides vaccine. All results indicated that KIF20A was a promising therapeutic target for multiple cancer.

2022年4月13日 · KIF20A, a kinesin with unique structural features, is overexpressed in human castration-resistant prostate cancer (CRPC) compared to androgen-dependent PC and benign tissue. KIF20A has...

2025年1月4日 · KIF20A promotes the proliferation and metastasis of bladder cancer cells. Bladder cancer patients with a high KIF20A expression have a worse tumour differentiation and a poor prognosis. High expression of KIF20A is associated with recurrence in pancreatic cancer.

2024年8月24日 · KIF20A, a mitotic kinesin overexpressed in various cancers, plays a pivotal role in cell division and is increasingly recognized as a crucial factor in tumor progression and a potential target for novel cancer treatments.

To investigate the expression of kinesin family member 20A (KIF20A) in bladder cancer, the effect of KIF20A on the proliferation and metastasis of bladder cancer cells, and the effect of KIF20A expression on the prognosis of bladder cancer patients.

2018年7月13日 · Here we report that mitotic kinesin KIF20A/MKLP2 interacts with RGS3 and plays a crucial role in controlling the division modes of NPCs during cortical neurogenesis.

2024年8月24日 · By concentrating on the significant potential of KIF20A as both a direct target for inhibitors and an antigen in cancer vaccines, this review sets a foundation for future research aimed at harnessing KIF20A for effective cancer treatment.

Core genes KIF20A of the model may have a role in mediating LUAD sensitivity to GEM and the combination of GEM and IKE synergistically induced LUAD cell death in vitro. Our study may provide new molecular and therapeutic strategies for …

2021年5月11日 · Here, we test this idea by targeting KIF20A, a mitotic kinesin crucial for the control of cell division modes, in a genetic model of medulloblastoma (MB) and human MB cells.