Kinesin-like protein KIF11 is a molecular motor protein that is essential in mitosis. In humans it is coded for by the gene KIF11. [5] [6] Kinesin-like protein KIF11 is a member of the kinesin superfamily, which are nanomotors that move along microtubule tracks in the cell.

2024年12月25日 · KIF11 (Kinesin Family Member 11) is a Protein Coding gene. Diseases associated with KIF11 include Microcephaly With Or Without Chorioretinopathy, Lymphedema, Or Impaired Intellectual Development and Microcephaly And Chorioretinopathy 1 .

What is KIF11 associated disorder? KIF11 associated disorder is a recently defined condition that affects the brain, eyes and lymphatic system. The condition is also known as Microcephaly, Chorioretinopathy, Lymphoedema and Mental Retardation (MCLMR).

KIF11 encodes EG5, a homotetramer kinesin motor. The variety of mutations we have found (two nonsense, two splice site, four missense, and six indels causing frameshifts) are all predicted to have an impact on protein function.

2025年1月13日 · KIF11 knockdown caused more EC cells to arrest in the G2/M phase and undergo apoptosis. The findings of our study emphasized that KIF11 may be a promising prognostic biomarker and therapeutic target for EC patients.

Kinesin family member 11 (KIF11) is a plus end-directed kinesin indispensable for the formation of the bipolar spindle in metaphase, where it objects to the action of minus end-directed molecular motors.

KIF11, a member of the kinesin family, plays a vital role in the formation and maintenance of the mitotic spindle. Recently, an increasing quantity of data have demonstrated the upregulated expression of KIF11 in various cancers, promoting the emergence and progression of cancers.