Alpha-ketoglutarate dehydrogenase (α-KGDH) is a Krebs cycle enzyme, which catalyses the non-equilibrium reaction converting α-ketoglutarate, coenzyme A and NAD + to succinyl-CoA, NADH and CO 2, requiring thiamine pyrophosphate as a cofactor. α-KGDH is not simply one of the enzymes of the Krebs cycle.

2017年12月6日 · Here we show that the α-ketoglutarate dehydrogenase (α-KGDH) complex is localized in the nucleus in human cell lines and binds to lysine acetyltransferase 2A (KAT2A, also known as GCN5) in the...

2024年11月1日 · α-Ketoglutarate dehydrogenase complex is a rate-determining enzyme in the tricarboxylic acid (Krebs) cycle. Photooxidation and 1 O 2 formation results in photolysis time- and O 2 -dependent loss of activity. Protein side-chain modifications were detected by LC-MS and aggregation by SDS-PAGE.

2005年12月29日 · Alpha-ketoglutarate dehydrogenase (alpha-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the Krebs cycle. It catalyses the conversion of alpha-ketoglutarate to succinyl-CoA and produces NADH directly providing electrons for the respiratory chain. alpha-KGDH is se …

The alpha-ketoglutarate dehydrogenase complex (KGDHC) is an important mitochondrial constituent, and deficiency of KGDHC is associated with a number of neurological disorders. KGDHC is composed of three proteins, each encoded on a different and well-characterized gene. The sequences of the human proteins are known.

2005年11月4日 · Alpha-ketoglutarate dehydrogenase (α-KGDH) is a highly regulated enzyme, which could determine the metabolic flux through the Krebs cycle. It catalyses the conversion of α-ketoglutarate to succinyl...

α-Ketoglutarate dehydrogenase (KGDH), a key regulatory enzyme within the Krebs cycle, is sensitive to mitochondrial redox status. Treatment of mitochondria with H₂O₂ results in reversible inhibition of KGDH due to glutathionylation of the cofactor, lipoic acid.

KGDHC may catalyze post-translational modification of itself as well as several other proteins by succinylation of lysine residues. The authors’ report of an enzyme responsible for succinylation of key mitochondrial enzymes represents a big step towards our understanding of the complex functional metabolome.

α-Ketoglutarate dehydrogenase (KGDH) dynamically regulates Jumonji C-domain-containing histone demethylase (JMJ)-dependent histone demethylation and gene expression in plants. Light promotes cytoplasmic KGDH translocation into the nucleus, where it catalyzes the oxidative decarboxylation of α-KG.

2018年7月9日 · In mitochondria, the α-ketoglutarate dehydrogenase complex (KGDH), a key control TCA enzyme, catalyses the oxidative decarboxylation of α-ketoglutarate (α-KG) to...