2017年6月7日 · The reduction of a ketone all the way down to an alkane using catalytic hydrogenation over palladium on charcoal is not a general/widely used process. Quoting from Comprehensive Organic Functional Group Transformations III :

2015年11月3日 · Reference 28 is: Concentration Dependence of Ketone Hydrogenation Catalyzed by Ru, Pd, and Pt. Evidence for Weak Ketone Adsorption on Pd Surface Bull. Chem. Soc. Japan, 55 (1982) 2275. Reference 29 is: V. Ponec and G.C. Bond, Catalysis by Metals and Alloys, Series: Studies in Surface Science and Catalysis, Vol. 95, Elsevier, Ansterdam, 1995.

2013年10月3日 · The Clemmensen reduction is really only effective at reducing ketones to alkenes when one group is aromatic. . Additionally, the Clemmensen reduction uses concentrated HCl, which might cause prob

2018年2月25日 · Each alkene has 2 fewer electrons than the alkane with the same number of carbons. Alkanes vs. Alkynes. As explained, since there is a bigger volume to an alkane than its corresponding alkyne (i.e. with the same number of carbons) the alkane should have a higher boiling point. However, there's something else in play here: Alkynes, have a TRIPLE ...

2018年2月15日 · Yes, you're correct. This does seem to be primarily aimed at alcohols. From the table, it's clear that they did not (1) reduce either at step 5 (2) ketone at step 4 (3) amide at step 6 (4) ester at step 12. Though, I'll wait for some conclusive evidence before the green checkmark. Thanks for answering though! :) $\endgroup$ –

2015年5月19日 · Typically, when thinking about ketone to alkene reactions, one thinks of the Wittig reaction. However, I don't see an appropriate form of that reaction here. This was posed as a question on my problem sheet and I suspect - after having given it some thought - that it's just a Hoffman/Saytzev question.

2016年9月25日 · Putting it all together, a recipe for selective borohydride reduction of a ketone in the presence of an aldehyde would be something like: Protect the aldehyde. The best choice is probably as a 1,3-dioxane acetal by reacting your compound with 4 equivalents of 1,3-propanediol, 1 equivalent of triethyl orthoformate, and 0.01 equivalent of ...

2013年11月18日 · $\begingroup$ Have a look at the comments to the answer of Rauru Ferro. He has posted a link that shows data which imply that it is not generally true that ketones have a higher boiling point than aldehydes - in fact they seem to be very similar and which one is higher changes within the homologous series.

2015年12月26日 · The key steps of the mechanism are given below, crucially showing that the alcohol is not an intermediate (hence why secondary alcohols are not able to undergo a Clemmensen reduction to afford the corresponding alkane). A single electron reduction of the ketone takes place to give a radical anion.

2019年4月23日 · Enzymatic conversion from aldehyde to ketone and back is common in the biochemistry of carbohydrates. In glycolysis, for example, phosphorylated dihydroxyacetone is converted to glyceraldehyde. Sugars have a hydroxyl group alpha to the carbonyl group. In the enzymatic reaction, isomerization proceeds via an enediol intermediate :