How are ketoanalogues different from branched-chain amino acids? Branched-chain amino acids (or BCAAs) are three of the essential amino acids: leucine, isoleucine, and valine. Their chemical structure is what makes them branched-chain amino acids.

Ketoanalogues of amino acids (KAs) are nitrogen-free analogs of essential amino acids.

Ketorena is a keto-analogue of essential amino acids used in combination with a low or very low protein renal diet. The combination of the diet and the keto-analogue is designed to slow the progression of CKD and improve nutrition without kidney toxic nitrogenous waste.

Essential amino acid and ketoacid mixtures are the most utilized types of supplementation in CKD patients on restricted protein regimens. The essential amino acids plus ketoacid supplementation is mandatory in conjunction with a very low-protein diet in order to assure an adequate essential amino acid supply.

2021年9月13日 · To assess whether a ketodiet, a combination of ketoanalogues of essential amino acids (KAs) and a very low-protein diet, retards progression of chronic renal failure and maintains nutritional status. GFR significantly decreased from 28.6 ± 17.6 to 22.5 ± 15.9 mL/min/1.73 m 2 in the placebo group (P = .015).

Ketoanalogues lack amino nitrogen. They take endogenous Nitrogen and get converted into essential aminoacids (EAA) in various tissues like Liver, Muscles and Intestines. This leads to effective utilization of nitrogen to form essential amino acids.

With CKD, getting proper nutrition can be difficult as your kidneys have lost their ability to rid the body of certain waste products. Ketorena is a keto-analogue designed to deliver essential amino acids without elevating blood urea nitrogen levels and …

2020年11月18日 · Keto acid analogs are nitrogen-free essential amino acids used in conjunction with a very low-protein diet. A diet lacking in nutrients, particularly calories or essential amino acids, can result in cachexia and a negative nitrogen load. The addition of KAAs can help improve deficiencies and nitrogen balance.

2022年9月22日 · In a nutshell, Keto-acids / Ketoanalogues lack the amino group bound to the alpha carbon of an amino acid so they can be converted to their respective essential amino acids without providing additional nitrogen that adds additional strain to the kidneys.

Different compositions of KAs and EAAs have been tested, with most of them containing four KAs (of the EAA isoleucine, leucine, phenylalanine, and valine), one hydroxyacid (of the EAA methionine), and four amino acids considered essential in CKD (tryptophan, threonine, histidine, and tyrosine) (Table 1). Figure 1.