Oct 20, 2021 · Here we show that, in mouse melanoma models, depletion of KDM5B—an H3K4 demethylase that is critical for melanoma maintenance and drug resistance 13, 14, 15 —induces robust adaptive immune...

Dec 25, 2024 · KDM5B (Lysine Demethylase 5B) is a Protein Coding gene. Diseases associated with KDM5B include Intellectual Developmental Disorder, Autosomal Recessive 65 and Autism Spectrum Disorder. Among its related pathways are Gene expression (Transcription) and RNA Polymerase I Promoter Opening.

The histone lysine demethylase, KDM5B, which catalyzes the demethylation of histone 3 lysine 4 (H3K4), is important for embryonic stem (ES) cell differentiation, and is a critical regulator of the H3K4-methylome during early mouse embryonic pre-implantation stage development. KDM5B is also overexpressed, amplified, or mutated in many cancer types.

Jul 1, 2022 · KDM5B is a histone modifying enzyme responsible for the demethylation of H3K4. Its gene regulatory functions play a vital role in normal embryonic development. KDM5B is implicated in the pathogenesis of diseases including developmental disorders. Model systems including disease models have been pivotal in exploring KDM5B function.

Dec 12, 2022 · In this review, we adopt a unique perspective regarding the context-dependent roles of KDM5A and KDM5B in development and tumorigenesis. It is well known that these two proteins show a high...

KDM5B induces the luminal transcriptional program by downregulating basal genes and upregulating luminal genes. KDM5B also contributes to therapeutic resistance by inducing transcriptomic heterogeneity. KDM5B and ER coordinately stimulate E2-dependent tumor growth. KDM5B and EMSY induce tumor invasiveness by repressing miR-31.

Nov 1, 2020 · KDM5B (lysine [K]-specific demethylase 5B) is frequently upregulated in various human cancers including prostate cancer. KDM5B controls H3K4me3/2 levels and regulates gene transcription and cell differentiation, yet the contributions of KDM5B to prostate cancer tumorigenesis remain unknown.

Feb 8, 2025 · Histone demethylase KDM5 regulates cardiomyocyte maturation by promoting fatty acid oxidation, oxidative phosphorylation, and myofibrillar organization. KDM5B promotes metastasis and epithelial-mesenchymal transition via Wnt/beta-catenin pathway in squamous cell carcinoma of the head and neck.

Mar 10, 2025 · KDM5B is a well-known histone demethylase and master regulator of histone modifications that functions as a key mediator of chromatin organization, transcriptional control, and genome stability ...

Dec 15, 2020 · KDM5B (Lysine-Specific Demethylase 5B) erases the methyl group from H3K4me2/3, which performs wide regulatory effects on chromatin structure, and represses the transcriptional function of genes. KDM5B functions as an oncogene and associates with human cancers closely.