2024年12月25日 · KAT2A (Lysine Acetyltransferase 2A) is a Protein Coding gene. Diseases associated with KAT2A include Chromosome 16P13.3 Deletion Syndrome, Proximal and Ohdo Syndrome, Sbbys Variant. Among its related pathways are Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants and RNA Polymerase I Promoter Opening.

Histone acetyltransferase KAT2A is an enzyme that in humans is encoded by the KAT2A gene. [5] [6]

2017年12月6日 · Here we show that the α-ketoglutarate dehydrogenase (α-KGDH) complex is localized in the nucleus in human cell lines and binds to lysine acetyltransferase 2A (KAT2A, also known as GCN5) in...

KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]

2024年6月10日 · Our study revealed an upregulation of lysine acetyltransferase 2 A (Kat2a) expression in DCM, accompanied by a decrease in N6-methyladenosine (m6A) modified Kat2a mRNA levels.

2025年2月4日 · In this study, we demonstrated that activation of epidermal growth factor receptor (EGFR) induced translocation of acetyl-CoA synthetase 2 (ACSS2) into the nucleus, where ACSS2 acted as a lactyl-CoA synthetase to produce lactyl-CoA and forms a complex with lysine acetyltransferase 2A (KAT2A).

2024年8月7日 · In this study, we find that double knockout (DKO) of lysine acetyltransferases 2A (Kat2a) and 2B (Kat2b) in the intestinal epithelium triggers an intrinsic IFN response and critically compromises intestinal function. Upon inactivation of Kat2 paralogs in the intestinal epithelium, the IFN pathway is activated, and intestinal stem cells are lost.

We focus on KAT2A, a lysine acetyltransferase responsible for histone H3 lysine 9 acetylation, which we recently identified as a dependence in acute myeloid leukemia stem cells and that participates in 2 distinct macromolecular complexes: Ada two-A-containing (ATAC) and Spt-Ada-Gcn5-Acetyltransferase (SAGA).

Our study proves that acetyltransferase KAT2A licenses metabolic and epigenetic reprogramming for NLRP3 inflammasome activation in inflammatory macrophages, thereby targeting KAT2A represents a potential therapeutic approach for patients suffering from RA and relevant inflammatory diseases.

2024年12月27日 · KAT2A, or GCN5, is a histone acetyltransferase (HAT) that functions primarily as a transcriptional activator. It also functions as a repressor of NF-kappa-B (see MIM 164011) by promoting ubiquitination of the NF-kappa-B subunit RELA (MIM 164014) in a HAT-independent manner (Mao et al., 2009 [PubMed 19339690]).[supplied by OMIM, Sep 2009]