Krüppel-like factor 4 (KLF4; gut-enriched Krüppel-like factor or GKLF) is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1 …

Dec 25, 2024 · KLF4 (KLF Transcription Factor 4) is a Protein Coding gene. Diseases associated with KLF4 include Glioma Susceptibility 1 and Epilepsy, Idiopathic Generalized 15. Among its …

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing transcription factor that regulates diverse cellular processes such as cell growth, proliferation, and …

Apr 8, 2023 · In this review, we will summarize the structural and functional aspects of KLF4, with a focus on KLF4 as a clinical biomarker and therapeutic target in different types of tumors.

KLF4 is an essential mediator of p53 in controlling G(1)/S progression of the cell cycle following DNA damage; KLF4 exerts a global inhibitory effect on macromolecular biosynthesis that is …

Feb 8, 2025 · Title: KLF4 regulates trophoblast function and associates with unexplained recurrent spontaneous abortion. KLF4-induced upregulation of SOCS1 ameliorates myocardial …

Sep 22, 2021 · We propose KLF4-mediated condensation as one mechanism for selectively organizing and re-organizing the genome based on the local sequence and epigenetic state.

Furthermore, Klf4 has been identified as an anti-proliferative shear stress-responsive gene, and forced over-expression of Klf4 in VSMCs induces growth arrest. Klf4 may therefore be an …

Krüppel-like factor 4 (KLF4) is a transcription factor highly conserved in evolution. It is particularly well known for its role in inducing pluripotent stem cells. In addition, KLF4 plays many roles in …

Krüppel-like factor 4 (KLF4) is a zinc finger–containing transcription factor that regulates a number of fundamental cellular processes (4, 5). It is best known for its role in controlling cell fate and …