2024年12月25日 · KIR3DL1 (Killer Cell Immunoglobulin Like Receptor, Three Ig Domains And Long Cytoplasmic Tail 1) is a Protein Coding gene. Diseases associated with KIR3DL1 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and …

Killer cell immunoglobulin-like receptor 3DL1 is a protein that in humans is encoded by the KIR3DL1 gene. [5] [6] [7] Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells.

抑制性kir2dl1、kir2dl2和kir2dl3识别hla-c作为它们的配体，而hla-b和hla-a作为其他kirs的配体，包括抑制性kir3dl1和kir3dl2。 除了NK细胞外，T细胞亚群和NKT细胞（不变自然杀伤性T细胞）也表达KIR。

2025年3月4日 · Title: Expression profile of KIR3DS1/KIR3DL1 receptors in association with immunological responses in TB, HIV and HIV/TB infected patients. HLA-Bw4 in association with KIR3DL1 favors natural killer cell-mediated protection against severe COVID-19.

2011年10月23日 · Here we describe the structure of a human KIR3DL1 receptor bound to HLA-B*5701 complexed with a self-peptide.

KIR3DL1 - killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 Gene

2023年11月23日 · Clinical resource with information about KIR3DL1, Susceptibility to HIV infection, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

UniProt is the world's leading high-quality, comprehensive and freely accessible resource of protein sequence and functional information.

studies indicate that KIR3DL1 expression may negatively regulate Treg function and suggest a previously undescribed target for improving immune tolerance for potential treatment of autoimmune diseases like IDDM; cloned Kir cDNAs from multiple strains of mice.

KIR3DL1 is a highly polymorphic receptor that binds to groups of HLAA and HLA-B allotypes that express the Bw4 epitope. The variation in KIR3DL1 allotypes manifests at a number of levels. Most dramatically, a common allelic variant encodes an activating rather than an inhibitory receptor (KIR3DS1).