TRIM28 - Wikipedia
TRIM28/KAP1 is a ubiquitously expressed protein involved in many critical functions including: transcriptional regulation, cellular differentiation and proliferation, DNA damage repair, viral …
KAP1 Protein: An Enigmatic Master Regulator of the Genome
In this minireview, we discuss how KAP1 might execute such pleiotropic effects, focusing on genomic targeting mechanisms, protein-protein interactions, specific post-translational …
TRIM28 Gene - GeneCards | TIF1B Protein | TIF1B Antibody
Dec 25, 2024 · Component of the TRIM28/KAP1-ERBB4-MDM2 complex involved in connecting growth factor and DNA damage responses. Interacts directly with ERBB4; the interaction …
KAP1/TRIM28: Transcriptional Activator and/or Repressor of
Feb 23, 2022 · One such regulator is Krüppel-associated box (KRAB)-associated protein 1 (KAP1: also named TRIM28 or TIF1β), which has been extensively studied in the past three decades. …
The ATM substrate KAP1 controls DNA repair in heterochromatin ...
KAP1 is a heterochromatin protein and co-repressor that binds to HP1 during gene silencing but is also robustly phosphorylated by Ataxia telangiectasia mutated (ATM) at serine 824 in …
KAP1 negatively regulates RNA polymerase II elongation ... - Nature
Jul 12, 2024 · KAP1 negatively regulates Pol II elongation kinetics at the earliest time points of cell stimulation to ultimately facilitate signal-induced transcription activation of IEGs.
PRKAR1B Gene - GeneCards | KAP1 Protein | KAP1 Antibody
Dec 25, 2024 · PRKAR1B (Protein Kinase CAMP-Dependent Type I Regulatory Subunit Beta) is a Protein Coding gene. Diseases associated with PRKAR1B include Marbach-Schaaf …
KAP1/TRIM28: Transcriptional Activator and/or Repressor of Viral …
We first summarize the discovery of KAP1 repression of endogenous retroviruses during development. We then deliberate evidence in the literature suggesting KAP1 is both an …
KAP1 controls endogenous retroviruses in embryonic stem cells
Jan 14, 2010 · KAP1 (KRAB-associated protein 1, also known as tripartite motif-containing protein 28, TRIM28) represses genes by recruiting the histone methyltransferase SETDB1, …
KAP1/TRIM28 – antiviral and proviral protagonist of herpesvirus …
Jun 12, 2024 · By recruiting epigenetic regulators, Krüppel-associated box (KRAB)-associated protein 1 (KAP1/TRIM28/TIF1β) is integral to the function of the HCM. Epigenetically silencing …