KRAS (Kirsten rat sarcoma virus) is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus.

The KRAS gene provides instructions for making a protein called K-Ras that is part of a signaling pathway known as the RAS/MAPK pathway. The protein relays signals from outside the cell to the cell's nucleus.

2021年11月15日 · As the most frequently mutated oncogene, Kirsten rat sarcoma viral oncogene homologue (KRAS) has attracted substantial attention. The understanding of KRAS is constantly being updated by...

2024年4月4日 · The most frequently mutated of these oncogenic driver genes, called KRAS, is associated with some of the most fatal cancer types: lung, pancreatic and colorectal cancers.

2021年2月12日 · KRAS mutations are present in approximately 25% of tumors, making them one of the most common gene mutations linked to cancer. They are frequent drivers in lung, colorectal and pancreatic cancers. KRAS drives 32% of lung cancers, 40% of colorectal cancers, and 85% to 90% of pancreatic cancer cases.

K-RAS is the most commonly mutated RAS isoform. The Ras protein is a membrane bound protein with inherent GTPase activity and is activated by numerous extracellular stimuli, cycling between an inactive (GDP-bound) and active (GTP-bound) form.

K-Ras is one of three Ras oncogenic isoforms (N- and H-Ras being the others). The human K-ras gene contains an alternative fourth coding exon, resulting in the production of two different splice variants termed K-Ras4A and K-Ras4B.

The KRAS gene (Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) is an oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is involved in the regulation of cell division as a result of its ability to relay external signals to the cell nucleus.

2025年1月22日 · What is a KRAS mutation? KRAS-positive lung cancer patient, Jennifer, shares what she would tell a newly diagnosed KRAS-lung cancer patient. Dr. Melissa Johnson discusses the past, present and future of treating KRAS-positive lung cancer. KRAS is an important biomarker in lung cancer.

2025年1月15日 · The discovery of DNA encoding RAS guanosine triphosphatases in rat sarcoma viruses and the identification of oncogenic mutations in RAS genes in patients with cancer sparked a 50-year effort to...