The JmjN domain as a dimerization interface and a targeted ... - PubMed
2018年3月30日 · Using the powerful bimolecular fluorescence complementation technique, we herein show the in situ formation of human KDM4A and KDM4C homodimers and …
JmjN interacts with JmjC to ensure selective proteolysis of
Here, we reveal that the JmjN and JmjC domains interact with each other through two β-sheets, one in each domain. Removal of either or both β-strands or the entire JmjN domain leads to …
Structural definitions of Jumonji family demethylase selectivity
2015年6月1日 · The JmjN domain is shown to be an integral core of all KDM catalytic domains. The Jumonji (Jmj) family of demethylases has a crucial role in regulating epigenetic processes …
The JmjN domain as a dimerization interface and a targeted …
2018年3月30日 · The JmjN domain was found as both essential and sufficient for dimerization, since its deletion in KDM4C abolished the enzyme’s dimerization capacity, while the individual …
JMJD family proteins in cancer and inflammation
2022年9月1日 · Here, we discuss the role of key JMJD proteins in cancer and inflammation, including the intensively studied histone lysine demethylases, as well as the understudied …
CDD Conserved Protein Domain Family: JmjN - National Center …
2020年10月2日 · To date, this domain always co-occurs with the JmjC domain (although the reverse is not true). smart00545 is a member of the superfamily cl15840. Jiyao W et al. …
The JmjN domain of Jhd2 is important for its protein stability
2010年8月6日 · Recent studies have identified Jhd2, a JmjC domain-containing protein, as an H3K4-specific demethylase in budding yeast. However, important questions regarding the …
The JmjN Domain of Jhd2 Is Important for Its Protein Stability, …
2010年8月6日 · Recent studies have identified Jhd2, a JmjC domain-containing protein, as an H3K4-specific demethylase in budding yeast. However, important questions regarding the …
SMART: JmjN domain annotation
JmJC domains are predicted to be metalloenzymes that adopt the cupin fold, and are candidates for enzymes that regulate chromatin remodelling. The cupin fold is a flattened beta-barrel …
JmjC-domain-containing proteins and histone demethylation
2006年9月1日 · Here we analyse the evolutionary relationship between Jumonji C (JmjC)-domain-containing proteins and discuss their cellular functions in relation to their potential enzymatic …
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