In hematology, hemophagocytic lymphohistiocytosis (HLH), also known as haemophagocytic lymphohistiocytosis (British spelling), and hemophagocytic or haemophagocytic syndrome, [1] is an uncommon hematologic disorder seen more often in children than in adults.

Hemophagocytic lymphohistiocytosis is a rare and often life-threatening condition if left untreated. HLH causes your immune system to attack your body instead of a foreign invader like a virus. The condition is either acquired or genetic and there’s no way to prevent it. Treatment is available and most effective with an early diagnosis.

Hemophagocytic lymphohistiocytosis (HLH) is a rare disorder of inflammation that was first thought to affect only young infants and children but is increasingly recognized in older children and adults.

2015年12月5日 · Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by extreme immune activation, resulting in pathologic inflammation. The diagnosis includes a spectrum of inherited or acquired defects in cytotoxic …

2020年8月1日 · Hemophagocytic lymphohistiocytosis (HLH) is a rare, life-threatening state of immune hyperactivation that arises in the setting of genetic mutations and infectious, inflammatory, or neoplastic triggers. Sustained, aberrant activation of cytotoxic CD8 + T cells and resultant inflammatory cytokine release are core pathogenic mechanisms.

Hemophagocytic lymphohistiocytosis (HLH) is a life threatening hyperinflammatory syndrome characterized by excessive activation of macrophages and T cells resulting from defective cytotoxicity.

2011年10月13日 · Here, we review the clinical manifestations and patterns of HLH and describe our approach to the diagnosis and therapy for this elusive and potentially lethal condition. Hemophagocytic lymphohistiocytosis (HLH) is a syndrome of pathologic immune activation characterized by clinical signs and symptoms of extreme inflammation.

Hemophagocytic lymphohistiocytosis (HLH) is a rapidly progressive hyperinflammatory syndrome which results in 100% case fatality rate if untreated [1]. Even with appropriate treatment, mortality may approach 50% [2]. Delay in diagnosis is thought to be one factor contributing to …

2019年9月18日 · Hemophagocytic lymphohistiocytosis (HLH) is an aggressive syndrome characterized by abnormal, excessive activation of the immune system.

Hemophagocytic lymphohistiocytosis (HLH) is a rare but potentially fatal disease of normal but overactive histiocytes and lymphocytes that commonly appears in...