Jasplakinolide 是一种海绵 Jaspis johnstoni 的大环肽天然产物，可诱导肌动蛋白聚合成微丝 (F-肌动蛋白)。 Jasplakinolide 与 F-肌动蛋白的一种不可逆稳定剂 Phalloidin 竞争结合 F-肌动蛋白，从而稳定该微丝并促进肌动蛋白的丝状装配。

Jasplakinolide is a potent actin polymerization inducer and stabilizes pre-existing actin filaments. Jasplakinolide binds to F-actin competitively with phalloidin with a K d of 15 nM. Jasplakinolide, a naturally occurring cyclic peptide from the marine sponge, …

Jasplakinolide, a cyclo-depsipeptide is a commonly used actin filament polymerizing and stabilizing drug. The substance has originally been isolated from a marine sponge, and can now be synthesized and has become commercially available. This, together with the benefit that jasplakinolide is membrane …

Jasplakinolide is a macrocyclic peptide isolated from the marine sponge Jaspis johnstoni and is a potent inducer of actin polymerization in vitro by stimulating actin filament nucleation. Jasplakinolide competes with phalloidin for actin binding (Kd

Jasplakinolide是一种从 Jaspis splendens 中分离出来的环缩肽，已被证明具有抗肿瘤活性。 它是一种肌动蛋白聚合和稳定化诱导剂。 它通过结合 F-肌动蛋白 (KD = 15 nM) 有效抑制 PC3 前列腺癌细胞的增殖 (IC50 = 35 …

Jasplakinolide paradoxically stabilizes actin filaments in vitro, but in vivo it can disrupt actin filaments and induce polymerization of monomeric actin into amorphous masses. A detailed analysis of the effects of jasplakinolide on the kinetics of actin polymerization suggests a resolution to this paradox.

Jasplakinolide是一种自然发生的宏环肽，它诱导肌动蛋白聚合成丝状（F-肌动蛋白）。 Jasplakinolide被证明与Phalloidin（sc-202763）竞争性地结合到F-肌动蛋白上，Phalloidin是一种不可逆的F-肌动蛋白稳定剂，用于稳定丝状并促进肌动蛋白的丝状组装。

Jasplakinolide | C36H45BrN4O6 | CID 9831636 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.

Chemically, jasplakinolide is a cyclo-depsipeptide containing a tripeptide moiety linked to a polypetide chain (8,10) . Jasplakinolide is also called jaspamide (9,10), however, in the recent literature exploring this substance the name jasplakinolide is preferably used (3,4,6,8,17,18), occasionally abreviated as JAS .

Jasplakinolide 是一种肌动蛋白特异性试剂，可促进肌动蛋白聚合，稳定肌动蛋白丝。 在体外 ，茉莉醛通过刺激肌动蛋白丝成核，强效诱导肌动蛋白聚合，与鬼笔环肽竞争肌动蛋白结合 (Kd = 15 nM)。