2024年9月12日 · The Janus kinase 2 (JAK2) gene directs cells to make the JAK2 protein, which stimulates cell growth and division. Learn what can cause a JAK2 gene mutation and associated conditions.

2024年12月25日 · JAK2 (Janus Kinase 2) is a Protein Coding gene. Diseases associated with JAK2 include Polycythemia Vera and Thrombocythemia 3. Among its related pathways are Signaling downstream of RAS mutants and Prolactin Signaling.

The JAK2 gene provides instructions for making a protein that promotes the growth and division (proliferation) of cells. This protein is part of a signaling pathway called the JAK/STAT pathway, which transmits chemical signals from outside the cell to the cell's nucleus.

JAK2 mutations can act as central drivers of myeloproliferative neoplasia, a pre-leukemic and age-related malignancy. Likewise, hyperactive JAK-signaling is a hallmark of immune diseases and critically influences inflammation, coagulation and thrombosis.

tyrosine-protein kinase JAK2, JAK-2, Janus kinase 2 (a protein tyrosine kinase) LncRNA BRE-AS1 regulates the JAK2/STAT3-mediated inflammatory activation via the miR-30b-5p/SOC3 axis in THP-1 cells. JAK2V617F Mutation in Endothelial Cells …

2025年2月20日 · Fatty Acid Binding Protein-4 Silencing Inhibits Ferroptosis to Alleviate Lipopolysaccharide-induced Injury of Renal Tubular Epithelial Cells by Blocking Janus Kinase 2/Signal Transducer and Activator of Transcription 3 Signaling.

2025年1月18日 · Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation.

3 天之前 · Explore the impact of JAK2 mutations on blood cell regulation, diagnostic strategies, and their relevance in myeloproliferative conditions and ongoing research. ... The JAK2 V617F mutation, a guanine-to-thymine substitution at nucleotide 1849, disrupts the protein’s autoinhibitory function, leading to constitutive activation of JAK-STAT, PI3K ...

JAK2 is a member of the Janus kinase (JAKs) family of non-receptor protein tyrosine kinases, which includes JAK1–3 and TYK2.

2023年11月13日 · One of the most commonly mutated proteins found in MPNs is the Janus kinase 2 (JAK2) protein. The discovery of JAK2 changed how doctors diagnose and treat people with MPNs, providing new options for people with this mutation.