Members of the Notch gene family encode transmembrane receptors that are critical for various cell fate decisions. The protein encoded by this gene is one of several ligands that activate Notch and related receptors. Two transcript variants encoding different isoforms have been found for this gene. [7] JAG2 has been shown to interact with NOTCH2.

2024年12月25日 · JAG2 (Jagged Canonical Notch Ligand 2) is a Protein Coding gene. Diseases associated with JAG2 include Muscular Dystrophy, Limb-Girdle, Autosomal Recessive 27 and Emery-Dreifuss Muscular Dystrophy. Among its related pathways are NOTCH2 Activation and Transmission of Signal to the Nucleus and Constitutive Signaling by …

Notch受体是一种跨膜受体，包括Notch1-4四种亚型，在信号通路的激活中起到核心作用。 JAG1-2和DLL1：编码Notch的配体，与Notch受体相互作用来启动信号通路。 JAG1和JAG2属于Jagged类配体，而DLL1属于Delta类配体. RBPJ：是Notch信号通路下游的关键效应分子。 当Notch受体被配体激活后，RBPJ与Notch内部域 (ICN)结合并从细胞浆转移到细胞核，参与靶基因的表达调控。 HES1/5 和 HEY1：编码基本环螺旋转录因子，是Notch信号通路下游效应分子中 …

经处理的受体随后通过内体转运到质膜，从而通过 Deltex 调控和 NUMB 抑制的方式与配体结合。在哺乳动物信号发送细胞中，Delta-like（DLL1、DLL3、DLL4）和 Jagged（JAG1、JAG2）家族成员可作为 Notch 信号转导受体的配体。

JAG2-mediated Notch activation confers phenotypic and functional aspects of Langerhans cell histiocytosis to dendritic cells. JAG2 is often expressed by CD138(+) primary cells. Our results indicate that spontaneous clonogenic growth of myeloma cells requires the expression of JAG2.

Notch 信号通路是一种细胞间信号机制，对胚胎的正常发育至关重要。 Notch 基因家族的成员编码对各种细胞命运决定至关重要的跨膜受体。 由该基因编码的蛋白质是激活 Notch 和相关受体的几种配体之一。 已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提供，2008 年 7 月] The Notch signaling pathway is an intercellular signaling mechanism that is essential for proper embryonic development.

2025年1月4日 · Clinical resource with information about JAG2, Muscular dystrophy, limb-girdle, autosomal recessive 27, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2024年4月19日 · Jag2-/-lung tumors exhibited higher frequencies of macrophages that expressed immunostimulatory mediators and triggered T cell-dependent anti-tumor immunity. Mechanistically, Jag2 ablation promoted Nr4a-mediated induction of …

2021年5月6日 · JAG2 encodes the Notch ligand Jagged2. The conserved Notch signaling pathway contributes to the development and homeostasis of multiple tissues, including skeletal muscle. We studied an international cohort of 23 individuals with genetically unsolved muscular dystrophy from 13 unrelated families.

2021年10月13日 · The JAG2 gene encodes a transmembrane protein that is a ligand for the Notch (see NOTCH1, 190198) family of transmembrane receptors that are critical for various cell fate decisions. Notch receptors are part of a conserved intercellular signaling mechanism that is essential for proper embryonic development in numerous metazoan organisms.