Feb 1, 2021 · The c-Jun N-terminal protein kinases (JNKs) JNK1 and JNK2 can act as either tumor suppressors or pro-oncogenic kinases in human cancers.

Sep 10, 2004 · JNK2 is preferentially bound to c-Jun in unstimulated cells, thereby contributing to c-Jun degradation. In contrast, JNK1 becomes the major c-Jun interacting kinase after cell …

Sep 15, 2006 · We show that JNK2 is a positive regulator of cJun expression and cellular proliferation. This conclusion contrasts with the results of previous studies of JNK2 based on …

Feb 19, 2021 · We have identified a novel JNK2-induced activation of SERCA2. The dual action of JNK2 in CaMKII-dependent arrhythmic SR Ca²⁺ leak and a CaMKII …

JNK1 and JNK2 are ubiquitously expressed in most tissues, whereas JNK3 expression is predominantly in brain, and, to a lesser extent, in the heart and testis 2. JNK signalling plays …

JNK1 and JNK2 have broad tissue distribution and play a potential role in insulin resistance, inflammation and cell signaling. JNK3 is predominantly found in the CNS neurons, making it …

应激活化蛋白激酶 (SAPK)/Jun 氨基末端激酶 (JNK) 是 MAPK 家族的成员，可由各种不同环境应激、炎症细胞因子、生长因子以及 GPCR 激动剂激活。 应激反应信号经 Rho 家族（Rac、Rho …

Oct 7, 2024 · JNK signaling, an integral component of the Mitogen-Activated Protein Kinase (MAPK) pathways, plays crucial roles in various cellular processes. Understanding this …

May 2, 2018 · JNK1/2 phosphorylation paralleled a marked reduction in MAP kinase phosphatase 1 (JNK dephosphorylator) expression in patients’ lungs. Association of JNK1/2 activation with …

Aug 31, 2011 · JNK2 activation by onset of laminar shear activates inflammatory signaling but also promotes the adaptive morphological response that downregulates inflammation. Only …