2024年12月25日 · ITGB4 (Integrin Subunit Beta 4) is a Protein Coding gene. Diseases associated with ITGB4 include Epidermolysis Bullosa, Junctional 5B, With Pyloric Atresia and Epidermolysis Bullosa, Junctional 5A, Intermediate. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

ITGB4 was transcriptionally activated by TFAP2A, and could promote LUAD progression and inhibit CD4 + /CD8 + T-cell infiltrations by activating the NF-κB signaling pathway. ITGB4 may serve as a potential immunotherapeutic target of LUAD.

2020年2月15日 · We developed two immunologic strategies to target ITGB4: ITGB4 protein-pulsed dendritic cells (ITGB4-DC) for vaccination and adoptive transfer of anti-CD3/anti-ITGB4 bispecific antibody (ITGB4 BiAb)-armed tumor-draining lymph node T cells.

2017年1月13日 · Our results indicated that ITGB4 induces HCC cell growth and invasiveness and promotes EMT via a mechanism involving the transcription factor Slug. ITGB4 promoted tumor growth in a xenograft...

2023年10月3日 · Integrin β4 (ITGB4) is a major component of hemidesmosomes and a receptor molecule of laminin. Studies have shown that laminin-5 interacts with ITGB4 to activate RAC1 activity and promote cell migration (Hamill et al., 2009) and polarization (Wu et al., 2018) by altering the cytoskeleton.

2024年8月6日 · Integrin β4 (ITGB4) is a transmembrane protein that functions as a mechanosensor, mediating the bidirectional exchange of information between the intracellular and extracellular matrices. ITGB4 plays a critical role in cell adhesion, migration, and signaling.

2024年1月3日 · The ITGB4 (Integrin subunit beta 4) gene encodes a receptor for laminins and its upregulation in tumor tissues is associated with poor prognosis. However, its role in glioma is not well...

The ITGB4 gene provides instructions for making one part (the β4 subunit) of a protein known as an integrin. Learn about this gene and related health conditions.

Itgb4 protein remains expressed in the early stages of peripheral regeneration and subsequent myelination. integrin beta4 is implicated in and associated with p53 in autophagy of lung cancer cells; ITGB4 SNP seems to influence tumour aggressiveness and survival in …

ITGB4-overexpressing CAF-conditioned medium promoted the proliferation, epithelial-to-mesenchymal transition, and invasion of breast cancer cells. In a co-transplant mouse model, MDA-MB-231 made a bigger tumor mass with CAFs than ITGB4 knockdown MDA-MB-231.