Alpha-7 integrin is a protein that in humans is encoded by the ITGA7 gene. [5][6] Alpha-7 integrin is critical for modulating cell-matrix interactions. Alpha-7 integrin is highly expressed in cardiac muscle, skeletal muscle and smooth muscle cells, and localizes to …

2024年12月25日 · ITGA7 (Integrin Subunit Alpha 7) is a Protein Coding gene. Diseases associated with ITGA7 include Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency and Congenital Myopathy 4A, Autosomal Dominant. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway.

Congenital muscular dystrophy with integrin alpha-7 deficiency is a rare, genetic, congenital muscular dystrophy due to extracellular matrix protein anomaly characterized by early motor development delay and muscle weakness with mild elevation of serum creatine kinase, that may be followed by progressive disease course with predominantly proxima...

2025年2月8日 · Title: ITGA7 relates to disease risk, pathological feature, treatment response and survival in Ph(-) acute lymphoblastic leukemia. Decrease in ITGA7 Levels Is Associated with an Increase in alpha-Synuclein Levels in an MPTP-Induced Parkinson's Disease Mouse Model and SH-SY5Y Cells.

Clinical resource with information about Congenital muscular dystrophy due to integrin alpha-7 deficiency and its clinical features, ITGA7, available genetic tests from US and labs around the world and links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, clinicaltrials.gov, PharmGKB

2024年9月17日 · ITGA7 relates to disease risk, pathological feature, treatment response and survival in Ph (-) acute lymphoblastic leukemia. Transcriptome profiles of stem-like cells from primary breast cancers allow identification of ITGA7 as …

2022年12月6日 · The complete absence of the integrin α7 protein in muscle supports the ITGA7 mutations are pathogenic. We performed electrocardiography, echocardiography, or cardiac magnetic resonance imaging, and histological biopsy analyses in patients with ITGA7 deficiency and Itga7 -/- mice.

2024年10月15日 · ITGA7 expression was linked to cancer-associated fibroblast infiltration. ITGA7-Related Gene Enrichment Analysis indicated that ITGA7 expression-correlated and functional binding genes were enriched in homotypic cell-cell adhesion, focal adhesion, and ECM-receptor interaction.

2021年7月12日 · ITGA7 was found to be significantly downregulated in BCSCs, and low expression significantly correlated with reduced survival in patients treated with chemotherapy, and with chemoresistance in...

2016年12月7日 · By comparing differentially expressed genes affected by non-CG methylation between tumour and corresponding non-tumour tissues in oesophageal squamous cell carcinoma (OSCC), we find that Integrin...