2024年12月25日 · ITGA5 (Integrin Subunit Alpha 5) is a Protein Coding gene. Diseases associated with ITGA5 include Lung Cancer and Lynch Syndrome 8. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Integrin Pathway. Gene Ontology (GO) annotations related to this gene include integrin binding and epidermal growth factor receptor …

整合素亚基α5： 该基因的产物属于整合素α链家族。整合素是由一个α亚基和一个β亚基组成的异二聚体整合膜蛋白，在细胞表面粘附和信号传导中发挥作用。编码的前原蛋白经过蛋白水解处理，生成包含 alpha 5 亚基的轻链和重链。该亚基与 β1 亚基结合形成纤连蛋白受体。这种整合素可能促 …

Integrin alpha-5 is a protein that in humans is encoded by the ITGA5 gene. [5] The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This …

2025年2月1日 · Itga5 + synovial fibroblasts (Fbs) regulate synovial inflammation and tissue remodelling in different stages of collagen-induced arthritis (CIA).

2025年2月9日 · Title: TLN1 synergizes with ITGA5 to ameliorate cardiac microvascular endothelial cell dysfunction. Integrin alpha5 regulates motility of human monocyte-derived Langerhans cells during immune response.

ITGA5 promotes tumor angiogenesis in cervical cancer. The members of the miR-148/152 family inhibit cancer stem cell-like properties in gastric cancer via negative regulation of ITGA5. ITGA5 and ITGB1 contribute to Sorafenib resistance by promoting vasculogenic mimicry formation in hepatocellular carcinoma.

2021年3月12日 · Our study demonstrated that ITGA5 may act as an essential regulator of tumor immune cell infiltration and a valuable prognostic biomarker in gastrointestinal tumors. Additional work is needed to fully elucidate the underlying mechanisms behind these observations.

2023年11月20日 · Our RNA-sequencing data identified Itga5 as one of the highest expressed and most upregulated members of the integrin family in macrophages infiltrating the healing infarct. Flow cytometry and ...

Integrin Subunit Alpha 5 (ITGA5), belongs to the integrin alpha chain family, is vital for promoting cancer cell invasion, metastasis. However, the correlation between ITGA5 expression and immune infiltration in gastrointestinal tumors remain ...

整合素α5(integrin alpha5, ITGA5)为整合素的主要亚单位之一，是细胞内最常见的细胞外基质蛋白异二聚体跨膜受体。ITGA5通过与细胞外基质相互作用调节细胞骨架组织、细胞迁移、细胞凋亡和信号转导。