2023年5月1日 · Isoproterenol is a beta-1 and beta-2 adrenergic receptor agonist indicated primarily for bradydysrhythmias. The administration and subsequent post-administration …

2022年9月12日 · C57BL/6 mice were used to establish mice model of chronic heart failure. We injected isoproterenol subcutaneously in a dose gradient of 250 mg/kg, 200 mg/kg, 150 mg/kg, …

A prolonged or excessive adrenergic activation leads to myocyte loss and heart dysfunction; however, how it contributes to heart failure remains poorly defined. Here we show that …

To assess the possible contribution of the circulatory and cardiac renin-angiotensin system (RAS) to the cardiac hypertrophy induced by a beta-agonist, the present study evaluated the effects …

Isoproterenol is a medication that increases the strength of your heart muscle to treat heart failure. This condition occurs when your heart doesn’t pump very well. A healthcare provider will give …

These results show that the conventional isoproterenol-induced HF model increases diaphragm contraction, a finding contrary to what is observed in patients with HF. Therefore, this specific …

2008年9月2日 · A continuum exists between the effects of the predominantly α 1-stimulation of phenylephrine (intense vasoconstriction) to the β-stimulation of isoproterenol (marked increase …

2023年11月2日 · Cardiac inflammation contributes to heart failure (HF) induced by isoproterenol (ISO) through activating β-adrenergic receptors (β-AR). Recent evidence shows that myeloid …

Isoproterenol treatment increases heart wall thickness and subcutaneous mini-pump implanted mice develop hypertrophic hearts. We next examined whether delivery method, ISP dose, or a …

2024年5月1日 · The isoproterenol (ISO)-induced myocardial fibrosis is considered a reliable and repeatable experimental model characterized by a relatively low mortality rate. Although is well …