An isolated brain is a brain kept alive in vitro, either by perfusion or by a blood substitute, often an oxygenated solution of various salts, or by submerging the brain in oxygenated artificial cerebrospinal fluid (CSF). [1] It is the biological counterpart of brain in a vat.

Brain microvessels have been isolated from fresh animal brain, fresh human brain obtained at neurosurgery, as well as fresh or frozen autopsy human brain. Brain microvessels are the starting point for isolation of brain microvessel RNA, which then enables the production of BBB cDNA libraries and a genomics analysis of the brain microvasculature.

2020年5月27日 · Recent studies made us question whether an isolated brain can have a life of its own after the body dies. Can it be alive on its own? Let’s find out. Our brain is the “operating center” of our body, it manages most of the conscious and unconscious functions we perform. We can’t have a transplant, at least not yet. Neurons stay alive ...

2023年11月2日 · Researchers led by a team at UT Southwestern Medical Center have developed a device that can isolate blood flow to the brain, keeping the organ alive and functioning independent from the rest of the body for several hours.

2024年9月30日 · The human body is an incredibly complex system, and replicating all its functions to support an isolated brain is a Herculean task. First off, there’s the issue of tissue degradation. Without the body’s natural repair mechanisms, brain tissue can start breaking down faster than a sandcastle at high tide.

2019年7月17日 · Paradoxically, this teamwork has produced a field focused nearly exclusively on mapping the brain as if it evolved in isolation. Here, we discuss promises and challenges in advancing our understanding of how human minds connect during social interaction.

The Isolated Brain and Its Aftermath. In: Worden, F.G., Swazey, J.P., Adelman, G. (eds) The Neurosciences: Paths of Discovery, I. Birkhäuser Boston. https://doi.org/10.1007/978-1-4684-6817-5_15 Download citation

2024年10月15日 · To study brain capillary-specific mitochondrial function and dynamics in response to oxidative stress, we developed an ex vivo model in which we used isolated brain capillaries from transgenic mice that express dendra2 green specifically in mitochondria (mtD2g).

The use of an isolated brain has many advantages: virtually all brain areas are easily accessible; tracer applications are possible without problems of animal survival; and the tracers are be translocated by blood circulation.

2001年12月24日 · The use of an isolated brain has many advantages: virtually all brain areas are easily accessible; tracer applications are possible without problems of animal survival; and the tracers are be translocated by blood circulation.