May 7, 2024 · Here we report that, in mammalian cells, formation of IRE1α clusters is an ER membrane-bound phase separation event that is coupled to the assembly of stress granules (SGs). In response...

Inositol-requiring enzyme type 1 (IRE1) is a serine/threonine kinase acting as one of three branches of the Unfolded Protein Response (UPR) signaling pathway, which is activated upon endoplasmic reticulum (ER) stress conditions.

Oct 16, 2024 · Here, we identify the ER stress sensor IRE1α as a critical checkpoint that restricts the immunostimulatory effects of taxane chemotherapy and prevents the innate immune recognition of immunologically cold triple-negative breast cancer (TNBC).

Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer during endoplasmic reticulum functional upset (ER stress). A IRE1α signal pathway arbitrates yin and yang of cellular fate in objectionable conditions.

Nov 9, 2015 · IRE1α, the most conserved UPR sensor, is a type-1 transmembrane ER-resident protein with bifunctional cytosolic kinase and RNase domains. IRE1α is associated with the ER chaperone BiP (or...

Ire1a and ire1b double mutant displays short roots and a ER stress-sensitive phenotype (PubMed: 21914012). Showing features for mutagenesis. Loss of autophosphorylation activity. We now provide the "Disease & Variants" viewer in its own tab. The viewer provides 60 variants from UniProt as well as other sources including ClinVar and dbSNP.

Oct 28, 2022 · 研究发现内质网应激状态下，IRE1α被激活并诱导XBP-1 mRNA形成剪接形式的XBP-1s，通过直接与ERSE（内质网应激响应元件）相互结合，进一步增强内质网伴侣蛋白基因的转录，以应对内质网应激；另一方面，其RNase活性还可以选择性降解mRNA，这一过程称为RIDD（IRE1α依赖性调节降解）。 有研究发现在损伤诱导的肌肉再生过程中IRE1α高表 …

Oct 15, 2024 · Single-cell RNA-sequencing analysis reveals that targeting IRE1α in cancer cells reduces tumor-associated macrophage abundance. Consistently, the small molecule IRE1α inhibitor MKC8866, currently...

Here we discover that IRE1α, the sensor of the unfolded protein response (UPR), is a bona fide substrate of the Sel1L-Hrd1 ERAD complex. ERAD-mediated IRE1α degradation occurs under basal conditions in a BiP-dependent manner, requires both the intramembrane hydrophilic residues of IRE1α and the lectin protein OS9, and is attenuated by ER stress.

May 8, 2020 · Inositol-requiring transmembrane kinase endoribonuclease-1α (IRE1α) is the most prominent and evolutionarily conserved unfolded protein response (UPR) signal transducer during endoplasmic reticulum functional upset (ER stress). A IRE1α signal pathway arbitrates yin and yang of cellular fate in objectionable conditions.