
Iron-responsive element-binding protein - Wikipedia
ACO1, or IRP1, is a bifunctional protein that functions as an iron-responsive element (IRE)-binding protein involved in the control of iron metabolism by binding mRNA to repress translation or degradation. It functions also as the cytoplasmic isoform of aconitase.
Iron response element - Wikipedia
In molecular biology, the iron response element or iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (untranslated regions) of various mRNAs whose products are involved in iron metabolism .
Iron-Responsive Element-Binding Protein - ScienceDirect
TfR numbers are modulated by post-transcriptional regulation of TfR mRNA. In the setting of low cellular and cytosolic iron, the iron responsive element-binding protein (IRE-BP) binds to a 3′ regulatory untranslated region in TfR mRNA, increasing mRNA stability, and leading to increased transcription and greater receptor numbers [14 ...
Iron regulatory protein (IRP)-iron responsive element (IRE) …
2017年10月23日 · Iron homeostasis is maintained by iron regulatory proteins (IRP1 and IRP2) and the iron-responsive element (IRE) signaling pathway. IRPs can bind to RNA stem-loops containing an IRE in the untranslated region (UTR) to manipulate translation of target mRNA.
Homology between IRE-BP, a regulatory RNA-binding protein, …
Iron-responsive elements (IREs) are regulatory RNA elements which serve as specific binding sites for the IRE-binding protein (IRE-BP). Interaction between IREs and IRE-BP induces repression of ferritin mRNA translation and transferrin receptor mRNA stabilization. We describe the identification of extensive amino acid sequence homology between ...
The iron-responsive element-binding protein: localization of the …
1994年1月18日 · The iron-responsive element-binding protein (IRE-BP) binds to specific stem-loop RNA structures known as iron-responsive elements (IREs) present in a variety of cellular mRNAs (e.g., those encoding ferritin, erythroid 5-aminolevulinate synthase, and …
The iron-responsive element binding protein ... - ScienceDirect
1992年9月15日 · The iron-responsive element binding protein (IRE-BP) is a cytosolic protein that binds a highly conserved sequence in the untranslated regions of mRNAs involved in iron metabolism including ferritin, transferrin receptor, and erythroid 5-aminolevulinate acid synthase.
Overexpression of iron-responsive element-binding protein …
We describe here overexpression of IRE-BP in baculovirus-infected insect cells which yields IRE-BP devoid of an iron-sulfur cluster. We describe a one-step purification of the IRE-BP and a quantitative analysis of Fe, S2-, S0, protein, and enzyme activity on IRE-BP, as obtained in cell lysates, after purification, and after reconstitution to ...
A regulated RNA binding protein also possesses aconitase
1991年11月15日 · A clone for the iron-responsive element (IRE)-binding protein (IRE-BP) has been transfected and expressed in mouse fibroblasts. The IRE-BP gene product binds IREs with high affinity and specificity. Amino acid alignments reveal that the IRE-BP is 30% identical to mitochondrial aconitase.
Modulation of the RNA-binding activity of a regulatory protein by …
1992年5月15日 · The iron-responsive element-binding protein (IRE-BP) is an RNA-binding protein that regulates the expression of several mRNAs in response to availability of cellular iron. The iron-dependent control of IRE-BP activity has been reconstituted in vitro.