Interleukin 2 - Wikipedia
Interleukin-2 (IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system. It is a 15.5–16 kDa protein [5] that regulates the activities of white blood cells (leukocytes, often lymphocytes) that are responsible for immunity.
Definition of interleukin-2 - NCI Dictionary of Cancer Terms
One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. Interleukin-2 is made by a type of T lymphocyte. It increases the growth and activity of other T lymphocytes and B lymphocytes, and affects the development of the immune system.
A systematic review of interleukin-2-based immunotherapies in ...
2023年3月31日 · High-dose interleukin-2 (IL-2) was the first approved immunotherapy for treatment of cancer. Apart from activating effector immune cells, IL-2 also stimulates regulatory T (Treg) cells, thus potentially limiting its efficacy as cancer treatment but offering opportunities to treat autoimmune diseases.
Interleukin 2: from immunostimulation to immunoregulation and ...
Interleukin 2 (IL-2) was one of the first cytokines to be discovered. However, the complex role of IL-2 and its receptor in the regulation of immune responses is only now emerging. This review explores the various signals triggered by IL-2 and discusses their …
Biology and regulation of IL-2: from molecular mechanisms to ...
2018年8月8日 · Ray, J. P. et al. The interleukin-2-mTORc1 kinase axis defines the signaling, differentiation, and metabolism of T helper 1 and follicular B helper T cells. Immunity 43, 690–702 (2015).
Role of IL-2 in cancer immunotherapy - PMC - PubMed Central …
Interleukin-2 (IL-2) is one of the key cytokines with pleiotropic effects on immune system. It has been approved for the treatment of metastatic renal cell carcinoma and metastatic melanoma. Recent progress has been made in our understanding of IL-2 ...
Interleukins in cancer: from biology to therapy | Nature ...
2021年6月3日 · Interleukins can nurture an environment enabling and favouring cancer growth while simultaneously being essential for a productive tumour-directed immune response. These properties of...