2024年12月25日 · Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands.

2023年1月2日 · The first identification of integrin family member is αIIbβ3, and the first integrin-targeting drug was Abciximab, approved in 1994 as an αIIbβ3 antagonist. 23 Intravenous αIIbβ3 inhibition has...

The beta 3 integrins, alpha IIb beta 3 and alpha V beta 3, are prominently expressed on the surfaces of platelets and endothelial cells, respectively. This vascular localization places them in a strategic position to perform adhesive functions necessary for hemostasis, wound healing and angiogenesis …

2023年8月16日 · In this work, we demonstrate that binding of the integrin β 3 cytoplasmic domain to Gα 13 through its ExE motif, directly disrupts the interaction between p115RhoGEF and Gα 13, thus inhibiting...

2019年3月7日 · Integrin αIIbβ3 and its signaling pathways are considered promising targets for antithrombotic therapy. This review describes the bidirectional signal transduction of integrin αIIbβ3 in platelets, as well as the proteins responsible for its regulation and therapeutic agents that target integrin αIIbβ3 and its signaling pathways.

Here, we establish integrin beta 3 (β3) subunit as a marker and regulator of senescence. Our findings highlight the importance of the β3 subunit signaling in regulating senescence by activating the transforming growth factor β (TGF-β) pathway in an …

The primary sequence of integrin beta 3 (ITGB3), a well-preserved region in all integrin beta subunits, has been called the RGD crosslinking region. Based on this information, we genetically modified MSCs using ex vivo lentiviral transduction to overexpress ITGB3.

2007年2月6日 · Integrin alpha-IIb/beta-3 (ITGA2B:ITGB3) is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins alpha-IIb/beta-3 and alpha-V/beta-3 recognize the sequence R-G-D in a wide array of ligands.

The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins.

2025年2月8日 · Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets.