CTCF is thought to be a primary part of the activity of insulators, sequences that block the interaction between enhancers and promoters. CTCF binding has also been both shown to …

2015年6月5日 · CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor …

2022年4月5日 · CTCF mediates chromatin insulation and long-distance enhancer-promoter (EP) interactions; however, little is known about how these regulatory functions are partitioned …

6 天之前 · In the context of population variation, the human-specific CTCF site in GM12878 contributed to the formation of a distinct architectural stripe, emphasizing its robust insulator …

2024年8月23日 · By genetically dissecting a couple of representative loci in mouse embryonic stem cells, we show that CTCF sites prevent undesirable enhancer-gene contacts (i.e. …

2021年5月17日，美国加州路德维希癌症研究所任兵教授团队在 Nature Genetics 期刊发表了题为：CTCF mediates dosage- and sequence-context-dependent transcriptional insulation by …

2020年3月23日 · Using CRISPR DNA-fragment editing, in conjunction with chromosome conformation capture, we find that CTCF sites, if located between enhancers and promoters in …

2008年7月25日 · Here we report that the CCCTC-binding factor (CTCF), a protein that binds insulator elements to prevent the spreading of heterochromatin and restricting transcriptional …

Insulation defects scaled with the degree of CTCF depletion and samples with around 15% CTCF preserved more insulation than completely depleted cells (with some boundaries more …

2025年2月28日 · CTCF is considered as the most essential transcription factor regulating chromatin architecture and gene expression. However, genome-wide impact of CTCF on …