2024年12月25日 · INPP5D (Inositol Polyphosphate-5-Phosphatase D) is a Protein Coding gene. Diseases associated with INPP5D include Hematologic Cancer and Crohn's Disease. Among its related pathways are Interleukin-2 family signaling and superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism.

2023年11月29日 · Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, we find that reduction in INPP5D activity is associated with molecular profiles...

In a Tyrobp Inpp5d -deficient TREM2 loss-of-function mouse model, haplodeficiency restored the association of microglia with Ab plaques, partially restored plaque. compaction, and astrogliosis, and reduced phosphorylated tau dystrophic neu-rites.

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia. Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia. Human Cytomegalovirus Mediates Unique Monocyte-to-Macrophage Differentiation through the PI3K/SHIP1/Akt Signaling Network.

2024年12月9日 · The gene inositol polyphosphate-5-phosphatase D (INPP5D), which encodes the lipid phosphatase SH2-containing inositol polyphosphate 5-phosphatase 1 (SHIP1), is associated with the risk of Alzheimer’s disease (AD). How it influences microglial function and brain physiology is unclear.

2022年11月30日 · Introduction: The inositol polyphosphate-5-phosphatase D (INPP5D) gene encodes a dual-specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins. Single nucleotide polymorphisms in INPP5D impact risk for developing late onset sporadic Alzheimer's disease (LOAD).

Specifically, inositol polyphosphate-5-phosphatase (INPP5D), also known as SHIP1, is selectively expressed in brain microglia and has been reported to be associated with LOAD. Although INPP5D is likely a crucial player in AD pathophysiology, its role in disease onset and progression remains unclear.

2024年1月26日 · Inhibiting microglial AD gene INPP5D activates the inflammasome. In AD brain, INPP5D expression is up, but active protein is down. This triggers the inflammasome, worsening inflammation. In human microglia generated from iPSCs, dunking SHIP1 drove …

INPP5D by western blot and tandem mass tag-mass spectrometry (TMT-MS). We compared INPP5D levels across three categories: low pathology, not cognitively impaired (LP-NCI), high pathology,...

2024年12月27日 · Title: Expression of INPP5D Isoforms in Human Brain: Impact of Alzheimer's Disease Neuropathology and Genetics. Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases.