2024年12月25日 · INPP5D (Inositol Polyphosphate-5-Phosphatase D) is a Protein Coding gene. Diseases associated with INPP5D include Hematologic Cancer and Crohn's Disease. Among its related pathways are Interleukin-2 family signaling and superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism.

2023年11月29日 · Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, we find that reduction in INPP5D activity is associated with molecular profiles...

2022年11月30日 · Introduction: The inositol polyphosphate-5-phosphatase D (INPP5D) gene encodes a dual-specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins. Single nucleotide polymorphisms in INPP5D impact risk for developing late onset sporadic Alzheimer's disease (LOAD).

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia. Targeted PI3K/AKT-hyperactivation induces cell death in chronic lymphocytic leukemia. Human Cytomegalovirus Mediates Unique Monocyte-to-Macrophage Differentiation through the PI3K/SHIP1/Akt Signaling Network.

Specifically, inositol polyphosphate-5-phosphatase (INPP5D), also known as SHIP1, is selectively expressed in brain microglia and has been reported to be associated with LOAD. Although INPP5D is likely a crucial player in AD pathophysiology, its role in disease onset and progression remains unclear.

INPP5D by western blot and tandem mass tag-mass spectrometry (TMT-MS). We compared INPP5D levels across three categories: low pathology, not cognitively impaired (LP-NCI), high pathology,...

We discuss the role of SHIP1, the protein encoded by INPP5D, in phosphoinositide signaling and its involvement in microglial functions, and recent evidence suggesting that reduction of SHIP1 activity results in activation of the NLRP3 inflammasome.

2024年12月27日 · Title: Expression of INPP5D Isoforms in Human Brain: Impact of Alzheimer's Disease Neuropathology and Genetics. Targeted hyperactivation of AKT through inhibition of ectopic expressed SHIP1 induces cell death in colon carcinoma cells and derived metastases.

The single nucleotide polymorphisms rs35349669 and rs10933431 within Inositol Polyphosphate-5-Phosphatase D (INPP5D) are strongly associated with Alzheimer’s Disease risk. To better understand INPP5D expression in the brain, we investigated INPP5D ...

2023年11月29日 · Through unbiased analyses of RNA and protein profiles in INPP5D-disrupted iPSC-derived human microglia, we find that reduction in INPP5D activity is associated with molecular profiles consistent with disrupted autophagy and inflammasome activation.