2024年12月25日 · IL6ST (Interleukin 6 Cytokine Family Signal Transducer) is a Protein Coding gene. Diseases associated with IL6ST include Hyper-Ige Syndrome 4B, Autosomal Recessive, With Recurrent Infections and Hyper-Ige Syndrome …

Glycoprotein 130 (also known as gp130, IL6ST, IL6R-beta or CD130) is a transmembrane protein which is the founding member of the class of tall cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family.

Bioinformatics Analysis Identifies IL6ST as a Potential Tumor Suppressor Gene for Triple-Negative Breast Cancer. Mosaic IL6ST variant inducing constitutive GP130 cytokine receptor signaling as a cause of neonatal onset immunodeficiency with autoinflammation and dysmorphy.

2025年2月8日 · Contributes to interleukin-11 binding activity and interleukin-11 receptor activity. Involved in interleukin-6-mediated signaling pathway; intestinal epithelial cell development; and positive regulation of Notch signaling pathway.

Rodriguez, C., Grosgeorge, J., Nguyen, V. C., Gaudray, P., Theillet, C. Human gp130 transducer chain gene (IL6ST) is localized to chromosome band 5q11 and possesses a pseudogene on chromosome band 17p11.

2024年9月19日 · The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein.

2024年3月7日 · We explore how mutations in the IL6ST gene encoding for gp130, which cause severe immune deficiencies in humans, impair signalling without blocking cytokine binding. We use cryoEM to solve...

2020年6月1日 · Autosomal dominant hyper-IgE syndrome (AD-HIES) is typically caused by dominant-negative (DN) STAT3 mutations. Patients suffer from cold staphylococcal lesions and mucocutaneous candidiasis, severe allergy, and skeletal abnormalities. We report 12 patients from 8 unrelated kindreds with AD-HIES due to DN IL6ST mutations.

A new pathogenic variant of the IL6ST gene was identified in P1, P2, P3, P4, P5, P6, and P7 by the targeted sequencing of 84 genes implicated in monogenic human inborn errors of innate immunity, or Sanger sequencing.

Interleukin 6 cytokine family signal transducer (IL6ST) is a protein that serves as a co-receptor for interleukin-6 (IL-6), interleukin-11 (IL-11), and related cytokines.