Interleukin 6 receptor (IL6R) also known as CD126 (C luster of D ifferentiation 126) is a type I cytokine receptor. Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response.

2024年12月25日 · IL6R (Interleukin 6 Receptor) is a Protein Coding gene. Diseases associated with IL6R include Hyper-Ige Syndrome 5, Autosomal Recessive, With Recurrent Infections and Soluble Interleukin-6 Receptor, Serum Level Of, Quantitative Trait Locus. Among its related pathways are TGF-Beta Pathway and MIF Mediated Glucocorticoid Regulation.

Interleukin (IL-)6 is the major pro-inflammatory cytokine within the IL-6 family. IL-6 signals via glycoprotein 130 (gp130) and the membrane-bound or soluble IL-6 receptor (IL-6R), referred to as classic or trans-signaling, respectively.

IL-6R (trans-signaling) is a key regulator of reverse cholesterol transport in lipid-laden macrophages. Genetic variations of IL10 and IL6R genes in acute anterior uveitis in Han Chinese. Causal relationship of interleukin-6 and its receptor on …

IL-6 induces intracellular signaling pathways after binding to its membrane-bound receptor (IL-6R), which is only expressed on hepatocytes and certain subpopulations of leukocytes (classic signaling). Transduction of the signal is mediated by the membrane-bound β …

Interleukin-6 (IL-6) signaling is a critical target in inflammatory pathways. Today, tocilizumab (TCZ) and sarilumab (SAR), two IL-6 receptor-inhibiting monoclonal antibodies, are widely used in the treatment of rheumatoid arthritis (RA), with a favorable efficacy/safety profile.

Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in liver regeneration and in the metabolic control of the body. On target cells, IL-6 binds to an 80 kDa IL-6 receptor (IL-6R).