Dec 25, 2024 · IL4R (Interleukin 4 Receptor) is a Protein Coding gene. Diseases associated with IL4R include Ige Responsiveness, Atopic and Human Immunodeficiency Virus Type 1. Among …

We sought to provide a comprehensive analysis of the redundant and distinct roles of IL-4 and IL-13 in type 2 inflammation and report dupilumab mechanisms of action. Methods: Using …

Mar 6, 2020 · Interleukin (IL)-4 and IL-13 are well known for their key roles in type 2 immune responses, which result in resistance to helminth parasites and inactivation of toxins.

Jan 4, 2023 · Targeting interleukin 4 receptor alpha (IL-4Rα), an IL-4/IL-13 signalling axis, with dupilumab shows efficacy in AD. We investigated the importance of IL-4Rα signalling …

Feb 8, 2025 · Title: IgG memory B cells expressing IL4R and FCER2 are associated with atopic diseases.

Here we describe our current understanding of the organization of the IL-4 receptor, of the signaling pathways that are induced as a result of receptor occupancy, and of the various …

This article reviews existing therapies targeting IL4, IL4R, or IL4/IL4R signaling, and recent findings guiding the creation of novel therapies that specifically inhibit the type II IL4R, while …

Gene ID: 3566, updated on 8-Feb-2025. This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to …

Feb 8, 2025 · Clinical resource with information about IL4R, A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci., A …

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in …