2023年4月4日 · DoD IL4 overview. The Defense Information Systems Agency (DISA) is an agency of the US Department of Defense (DoD) that is responsible for developing and maintaining the DoD Cloud Computing Security Requirements Guide (SRG). The Cloud Computing SRG defines the baseline security requirements used by DoD to assess the …

The interleukin 4 (IL4, IL-4) is a cytokine that induces differentiation of naive helper T cells (T h 0 cells) to T h 2 cells. Upon activation by IL-4, T h 2 cells subsequently produce additional IL-4 in a positive feedback loop.

2024年12月25日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation.

STAT6 is so vital for the actions of IL-4 that Stat6-deficient mice phenocopy many of the defects observed with Il4- or Il4ra-deficient mice (e.g., related to Th2 differentiation and Ig class switch).

2021年9月7日 · Interleukin-4 (IL-4) is a four-α-helical bundle type I cytokine with broad pleiotropic actions on multiple lineages. Major actions of IL-4 were initially discovered for B and T cells, but this cytokine acts on more than a dozen different target cells spanning the innate and adaptive immune systems and is produced by multiple different cellular sources.

IL-4 plays important roles in a myriad of cellular events, making it difficult to study its effects, particularly in vivo, on any one system. Although this review focuses on its neurological functions, most of what is known about IL4 comes from studies of peripheral immune cells, such as macrophages and lymphocytes.

2025年2月8日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation.

IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation.

2003年7月1日 · Acute expression of the IL4 gene by differentiated T H 2 cells is regulated by many positive and negative inducible transcription factors, such as nuclear factor of activated T cells (NFAT ...

2024年12月10日 · IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation.

2025年2月7日 · Production of interleukin-4 (IL-4) results in the expansion of virtual memory CD8 T cells (T VM cells), which acquire a memory phenotype even in the absence of foreign antigen exposure. The mechanisms that regulate T VM cell expansion in response to IL-4 produced during parasitic helminth infection remain to be determined. Yang et al. performed scRNA-seq …

2020年3月6日 · A single Il4/Il13-related gene was found in spotted gar (Lepisosteus oculatus), an example of a bony fish that only went through two rounds of WGD, whereas two Il4/Il13-related genes (Il4/13a...

2012年11月1日 · IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning.

2020年8月10日 · IL-4 has been called the "prototypic immunoregulatory cytokine." Like many cytokines, it can affect a variety of target cells in multiple ways. IL-4 has an important role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses. It is produc …

Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4R alpha chain and the common gamma chain (gamma c), resulting in a series of phosphorylation events mediated by receptor-associated kinases.

Interleukin-4 (IL4) is a growth factor for both B and T lymphocytes. - High levels of IL4Rs have been observed on tumors derived from such cells. - IL4Rs are also overexpressed on activated T lymphocytes, which mediate autoimmune disorders.

Role of IL-4 in Cardiovascular Diseases. Interleukin 4, a typical Th2 cytokine, 41 promotes tissue fibrosis in diseases involving the lung, 42 skin, 3 and liver. 43 Inhibition of tissue fibrotic remodeling in the lung and skin due to IL-4 has been demonstrated in various animal studies. 34,44 Widely used in Japan by patients with asthma, 45,46 suplatast tosilate inhibits airway …

Abstract Interleukin-4 is a multifunctional cytokine that plays a critical role in the regulation of immune responses. Its effects depend upon binding to and signaling through a receptor complex consisting of the IL-4Rα chain and the common gamma chain (γc), resulting in a series of phosphorylation events mediated by receptor-associated kinases. In turn, these cause the …

The IL-4R is composed of two transmembrane proteins. IL-4Rα chain (red) binds IL-4 (blue) with high affinity, leading to dimerization with γ c (yellow) or IL-13Rα1 (green), forming the type I or II receptor complex, respectively. IL-13 (orange) binds to IL-13Rα1 with lower affinity, followed by heterodimerization with IL-4Rα to form a high-affinity complex.

2012年11月1日 · IL-4 has been extensively studied in the context of its role in immunity. Accumulating evidence indicates, however, that it also plays a critical role in higher functions of the normal brain, such as memory and learning. In this review, we summarize current knowledge of the basic immunology of IL-4, …

SNPs in IL4, IL13 and the receptor subunits are reportedly associated with glioma (111, 112). These polymorphisms highlight key features of IL-4/-13 receptor signaling that regulate disease susceptibility and severity, i.e. ligand binding, signaling and its regulation.