白介素33（interleukin 33，IL-33）是由人源基因 IL33编码的蛋白，其是IL-1家族成员，能有效驱动辅助因子Th2的产生。 白介素33是ST2的配体之一。 在非活性状态下，IL-33以前体形式（全长270个氨基酸残基），通过与染…

Interleukin 33 (IL-33) is a protein that in humans is encoded by the IL33 gene. [5] Interleukin 33 is a member of the IL-1 family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL-4). IL33 is a ligand for ST2 , an IL-1 family receptor that is highly expressed on Th2 cells, mast cells and group 2 innate ...

知乎，中文互联网高质量的问答社区和创作者聚集的原创内容平台，于 2011 年 1 月正式上线，以「让人们更好的分享知识、经验和见解，找到自己的解答」为品牌使命。知乎凭借认真、专业、友善的社区氛围、独特的产品机制以及结构化和易获得的优质内容，聚集了中文互联网科技、商业、 …

2024年12月25日 · Complete information for IL33 gene (Protein Coding), Interleukin 33, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

2016年9月19日 · Il33 −/− mice with dextran sodium sulfate (DSS)-induced acute colitis showed decreased mortality and inflammation but had delayed recovery at later phases 154.

The critical function of IL-33/ST2 signaling in allergic inflammation is illustrated by the fact that IL33 and IL1RL1 are among the most highly replicated susceptibility loci for asthma. In this review, we highlight 15 years of discoveries on IL-33 protein, including its molecular characteristics, nuclear localization, bioactive forms, cellular ...

2022年8月1日 · Cigarette smoke and infection are the major drivers of COPD. Loss of Il33 protects mice from smoke-induced exaggerated inflammatory responses to influenza virus infection, suggesting that IL-33 plays critical roles in pathogen-induced exacerbations of …

IL-33 may be important for allergic airway diseases in humans. Indeed, the IL33 and ST2/IL1RL1 genes were found to be associated with asthma and allergic rhinitis in several GWAS studies that included thousands of human subjects from diverse ethnic groups (29–33, 127). Below, we have discussed the studies that investigated the potential roles ...

Analysis of patient samples and studies in murine models support an important role of IL-33/ST2 signaling in allergic inflammation in different tissues (lung, nasopharynx, skin) and diseases (asthma, chronic rhinosinusitis, allergic rhinitis, atopic dermatitis). IL33 and IL1RL1/ST2 are among the most highly replicated susceptibility loci for ...

2022年9月16日 · 若要将IL33/ST2最大限度运用到肿瘤诊断及治疗，关键在于肿瘤微环境的研究及如何平衡其在Th1/Th2免疫应答中的作用，这或将成为未来肿瘤研究的关注点。