Interleukin (IL)-22 is a potent mediator of inflammatory responses. The IL-22 receptor consists of the IL-22Rα and IL-10Rβ subunits. Previous studies have shown that IL-22Rα expression is restricted to non-hematopoietic cells in the skin, pancreas, intestine, liver, lung, and kidney.

Interleukin-22 (IL-22) is a protein that in humans is encoded by the IL22 gene. [5][6] IL-22 is an α-helical cytokine. IL-22 binds to a heterodimeric cell surface receptor composed of IL-10R2 and IL-22R1 subunits. [7] . IL-22R is expressed on tissue cells, and it is absent on immune cells. [8]

2013年12月31日 · Data obtained over the past few years indicate that the IL-22–IL-22 receptor subunit 1 (IL-22R1) system has a high potential clinical relevance in psoriasis, ulcerative colitis,...

The IL-22 receptor (IL-22R) is a Type 2 cytokine receptor and member of the IL-10 family of receptors along with the receptors for IL-10, IL-19, IL-20, IL-24, IL-26, IL-28 and IL-29 (Figure 1). It is composed of two heterodimeric subunits, IL-22R1 and IL-10R2 (2, 3, 11 – 13).

Interleukin 22 receptor, alpha 1 is a protein that in humans is encoded by the IL22RA1 gene. [5] The protein encoded by this gene belongs to the class II cytokine receptor family, and has been shown to be a receptor for interleukin 22 (IL22).

Interleukin-22 receptor is a type II cytokine receptor. It binds to Interleukin-22. It is a heterodimer of α1 [1] and IL-10Rβ2 [1] subunits. ^ a b Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, …

2024年12月25日 · IL22RA1 (Interleukin 22 Receptor Subunit Alpha 1) is a Protein Coding gene. Diseases associated with IL22RA1 include Spondyloarthropathy and Erythematosquamous Dermatosis. Among its related pathways are Akt Signaling and …

Expression of interleukin (IL)-22, a member of the IL-10 cytokine family, has recently been reported in a number of human diseases, including mucosal-associated infections and inflammatory disorders of the intestine, skin, and joints.

IL22 promotes acinar to ductal metaplasia, stem cell features, and increased expression of markers of the epithelial-mesenchymal transition; inhibitors of STAT3 block these effects. Increased expression of IL22 by PDACs is associated with reduced survival times. Keywords: Cancer Stem Cell; EMT; Immune Response; Transcriptional Regulation.

2022年1月11日 · Interleukin (IL)-22 is a potent mediator of inflammatory responses. The IL-22 receptor consists of the IL-22Rα and IL-10Rβ subunits. Previous studies have shown that IL-22Rα expression is restricted to non-hematopoietic cells in the …