Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity to pathogens or contribute to the pathogenesis of ...

Apr 16, 2019 · Here, we discuss the functions of the IL-17 family, with a focus on the balance between the pathogenic and protective roles of IL-17 in cancer and autoimmune disease, including results of therapeutic blockade and novel aspects of IL-17 signal transduction regulation.

Interleukin-17 (IL-17) has emerged as a central player in the mammalian immune system. Although this cytokine exerts a host-defensive role in many infectious diseases, it promotes inflammatory pathology in autoimmunity and other settings. A myriad of studies have focused on how IL-17-producing cells are generated.

Interleukin-17 (IL-17) and IL-17-producing cells have been shown to play important roles in inflammation and the immune response. IL-17 is believed to be mainly produced by T helper 17 (Th17) cells, a unique helper T-cell subset different from Th1 and Th2 cells.

Jul 5, 2022 · IL-17A and IL-17F are produced by CD4 + and CD8 + T cells, γδ T cells, and various innate immune cell populations in response to IL-1β and IL-23, and they mediate protective immunity against fungi...

Oct 11, 2023 · Interleukin 17 (IL-17) is an important cytokine that has several roles in host defense responses against mucosal infections; additionally, it is a primary pathologic cytokine and therapeutic...

Nov 19, 2019 · IL-17 is a highly versatile pro-inflammatory cytokine crucial for a variety of processes, including host defense, tissue repair, the pathogenesis of inflammatory disease and the...

Mar 22, 2024 · IL-17 inhibitors block the inflammatory pathway of interleukin-17A. These biologic medications are an extremely effective FDA-approved treatment option for people with psoriasis and psoriatic arthritis.

The interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases.

5 days ago · Interleukin-17 (IL-17) inhibitors have emerged as a promising class of therapeutics for inflammatory and autoimmune diseases, offering targeted intervention where conventional treatments fall short. These inhibitors block IL-17 signaling, which plays a key role in conditions such as psoriasis, rheumatoid arthritis, and ankylosing spondylitis.